University of Leicester
A Medical Research Council CASE Studentship held jointly by Dr Simon Wagner, of the Department of Cancer Studies and Molecular Medicine, and Domainex, an innovative drug discovery company based in Cambridge. Building on the discovery of a potential survival pathway in a common type of non-Hodgkin's lymphoma, the project will use novel agents developed by Domainex to understand the mechanism of the drugs' action and define patient groups that are most likely to benefit.
Imperial College London
Professor Sivaramesh Wigneshweraraj's group at Imperial works with Domainex Ltd. and use the knowledge gained from studying the structural, molecular and genetic basis of the mechanisms by which phage-encoded small proteins inhibit the bacterial RNA polymerase, as an inspiration to develop truly new lead antibacterial compounds to target antibiotic resistant bacteria.