Domainex is seeking highly motivated and ambitious laboratory-based scientists with a passion for drug discovery research. We pride ourselves on our strong work ethic and our friendly, supportive environment where scientists are encouraged to develop skills and build their careers.
Based from our Medicines Research Centre on Chesterford Research Park, near Cambridge, we have doubled in size in the last two years and don’t plan to stop there.
Complementing an ambitious growth strategy, we are actively investing in our people and technologies, and looking to strengthen our Bioassay and Analytical Chemistry teams. If you would like to join us, and have the skills and experience we are looking for, we would love to hear from you.
Domainex require an experienced ADME/PK ‘hands-on’ scientist to lead the delivery of high-quality ADME/PK assay data into client-focused drug discovery projects in a just-in-time manner. The role shall require the ability to design, develop, conduct, analyse and report on in vitro ADME/PK studies. This exciting role will require cross-team collaboration with bioassay scientists, analytical and medicinal chemists, utilizing established automation and informatics systems. It will span various therapeutic areas, with projects at differing stages of the drug discovery process. The candidate will also need to work with colleagues in sales and marketing to generate case studies, generate marketing literature and provide input during the proposal stage of new projects.
Qualified to BSc or PhD level, all applicants must have prior industrial experience of performing/interpreting in vitro assays; including, but not limited to, metabolic stability, metabolite identification, CYP inhibition, drug transporters, reaction phenotyping and protein binding. Our ideal candidates will have established skills in cell-based in vitro assays including hepatocyte turnover and Caco-2 cell permeation models as applied to drug absorption. Ideally a senior candidate would have the following experience; (i) hands-on experience of mass spectrometry as applied to in vitro drug metabolism (ii) hands-on experience of bioanalytical method development and metabolite identification using LC/MS/MS (and/or QTof).
An ability to work across multiple projects is required and ideal candidates must possess excellent organisation, planning, communication and data analysis skills. Senior candidates will be expected to influence drug discovery projects and provide data interpretation to our customers via written reports and/or face-to-face communication.
To apply, please send your CV and a covering letter, quoting reference AN0817, to email@example.com
Domainex has full-time permanent job vacancies in Assay Biology. We offer our clients a comprehensive range of assay services including biochemical, biophysical and cell-based assay development, high-throughput screening, compound profiling (potency, selectivity, phenotype, and mechanism of action) and off-target ADME/safety assessment to support the generation of pre-clinical candidates.
These roles require the ability to plan and implement experimental programmes, to solve any problems that arise, and to work effectively within project teams to deliver high-quality data to our clients. Laboratory work is a major element of these varied and challenging roles, and most of our bioassays are run on automated instrumentation. Other essential attributes include diligent reporting of results, data interpretation and an ability to make recommendations for further studies. It will also be necessary to communicate your results effectively to our clients.
All applicants should ideally have some prior experience of doing biochemical, biophysical and/or cellular assays in at least one of the following categories; enzyme kinetics, receptor binding studies, biophysical assays, cellular efficacy and/or mechanism of action studies. Candidates must have experience of working with microtitre plate-based assays, preferably in a drug discovery setting, will have developed assays for compound screening and potency determination in a variety of formats, and should be proficient in data processing and analysis.
Minimum of BSc.
Independence; flexibility to take on different projects.
Able to make tangible contribution to projects worked on through timely delivery of high-quality results.
To apply for the Associate Scientist role, please sending your CV and a covering letter, quoting reference ABA0618, to firstname.lastname@example.org
BSc or PhD with a number of years of relevant and proven drug discovery experience.
Independence and team working; able to direct the work of others and make meaningful impact on clients.
Ability to deliver high quality results consistently.
Ability to take the initiative.
Creative thinking coupled to delivery of novel outcomes that leads to opportunities for inventorship or publications (papers/research articles).
To apply for the Senior Scientist role, please sending your CV and a covering letter, quoting reference SBA0618, to email@example.com
Established in 2001, Domainex is a privately-owned, rapidly growing drug discovery services company with expertise spanning disease target expression, hit discovery, hit-to-lead identification and lead optimisation.
We have established an excellent reputation for providing high-quality and innovative drug discovery services and have an established track record of delivering preclinical drug candidates for our partners. Our clients include leading universities, biotechnology and pharmaceutical companies in the UK and overseas.
As a fast-growing technology company, Domainex offers a stimulating environment in which to work. Scientists are encouraged to be innovators, work collaboratively and above all to deliver high quality data and results to our customers.
For all posts, we are legally obliged to confirm that the appointee is eligible to work in the UK before they start working for us. When applying for jobs it is important that you are aware of your eligibility status as government restrictions apply to the employment of migrant workers. If invited to interview, you will be required to provide proof of your eligibility to work in the UK on your arrival.
Due to the anticipated high number of applicants, we can only reply to candidates with the most relevant skills and experience. If you have not heard back from us within one month of submitting your application, please assume that you have been unsuccessful on this occasion.
Domainex is not accepting unsolicited assistance from search firms for any employment opportunities. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Domainex via email, the Internet or in any form and/or method without a valid written search agreement in place for any position will be deemed the sole property of Domainex. No fee will be paid in the event the candidate is hired by Domainex as a result of the referral or through other means.