Recruitment at Domainex – drug discovery CRO in Cambridge

Domainex is seeking highly motivated and ambitious laboratory-based scientists with a passion for drug discovery research. We pride ourselves on our strong work ethic and our friendly, supportive environment where scientists are encouraged to develop skills and build their careers.

Based from our Medicines Research Centre on Chesterford Research Park, near Cambridge, we have doubled in size in the last two years and don’t plan to stop there.

Complementing an ambitious growth strategy, we are actively investing in our people and technologies, and looking to strengthen our Bioassay and Analytical Chemistry teams.  If you would like to join us, and have the skills and experience we are looking for, we would love to hear from you.    

ADME/PK Scientist/Senior Scientist

Domainex require an experienced ADME/PK ‘hands-on’ scientist to lead the delivery of high-quality ADME/PK assay data into client-focused drug discovery projects in a just-in-time manner. The role shall require the ability to design, develop, conduct, analyse and report on in vitro ADME/PK studies. This exciting role will require cross-team collaboration with bioassay scientists, analytical and medicinal chemists, utilizing established automation and informatics systems. It will span various therapeutic areas, with projects at differing stages of the drug discovery process. The candidate will also need to work with colleagues in sales and marketing to generate case studies, generate marketing literature and provide input during the proposal stage of new projects.

Candidate Requirements

Qualified to BSc or PhD level, all applicants must have prior industrial experience of performing/interpreting in vitro assays; including, but not limited to, metabolic stability, metabolite identification, CYP inhibition, drug transporters, reaction phenotyping and protein binding.  Our ideal candidates will have established skills in cell-based in vitro assays including hepatocyte turnover and Caco-2 cell permeation models as applied to drug absorption. Ideally a senior candidate would have the following experience; (i) hands-on experience of mass spectrometry as applied to in vitro drug metabolism (ii) hands-on experience of bioanalytical method development and metabolite identification using LC/MS/MS (and/or QTof). 

An ability to work across multiple projects is required and ideal candidates must possess excellent organisation, planning, communication and data analysis skills.  Senior candidates will be expected to influence drug discovery projects and provide data interpretation to our customers via written reports and/or face-to-face communication.

To apply, please send your CV and a covering letter, quoting reference AN0817, to

Analytical Chemists

Domainex currently has full-time, permanent positions available immediately for analytical scientists. The roles involve the development, qualification and implementation of analytical methods suitable for bioassay applications and also the characterisation of compounds for biological testing.

Candidate requirements

Our ideal candidates will have a minimum BSc/MSc degree (in Chemistry or Analytical Chemistry) and industrial experience in an analytical chemistry laboratory. Experience in the operation of LC and preferably LCMS equipment, and proven LC method-development skills are essential.

An understanding of LCMS instrument maintenance and troubleshooting would be beneficial. It would be advantageous to be skilled in the undertaking and analysis of MS-based bioanalytical methods, e.g. to assess compound ADME parameters. An ability to work across multiple projects is required and ideal candidates must possess excellent organisation, planning, communication and data analysis attributes. Practical knowledge of other techniques such as NMR, GCMS, preparative HPLC, would be required. 

To apply, please send your CV and a covering letter, quoting reference AC1217, to

Assay Biologists

Domainex offers a suite of biology services covering recombinant protein expression, X-ray crystallography, biochemical, biophysical and cell-based assay development, high throughput screening, compound profiling (potency, selectivity, phenotype, and mechanism of action) and off-target ADME/safety assessment to support the generation of pre-clinical candidates.

Domainex has full-time permanent vacancies for assay biologists. The roles require the ability to plan and implement experimental programmes, to solve any problems that arise, and to work effectively within project teams to deliver high quality data to our clients. Other required attributes will include diligent reporting of results, data interpretation and an ability to make recommendations for further studies. Laboratory work is the major component of these varied and challenging roles, and most of our bioassays are run on automated instrumentation. It will also be essential to able to communicate results effectively to our clients.

Candidate requirements

Qualified to BSc or PhD level in a relevant life science discipline, all applicants ideally should have some prior experience of running biochemical, biophysical and/or cellular assays in at least one of the following categories; enzyme kinetics, receptor binding studies, biophysical assays or cellular efficacy and/or mechanism of action studies. Candidates must have experience of working with microtitre plate-based assays, ideally in a drug discovery setting, will have developed assays for compound screening and potency determination in a variety of formats, and will be proficient in data processing and analysis. 

To apply, please send your CV and a covering letter, quoting reference BA1217, to

Established in 2001, Domainex is a privately-owned, rapidly growing drug discovery services company with expertise spanning disease target expression, hit discovery, hit-to-lead identification and lead optimisation.

We have established an excellent reputation for providing high-quality and innovative drug discovery services and have an established track record of delivering preclinical drug candidates for our partners. Our clients include leading universities, biotechnology and pharmaceutical companies in the UK and overseas.

As a fast-growing technology company, Domainex offers a stimulating environment in which to work. Scientists are encouraged to be innovators, work collaboratively and above all to deliver high quality data and results to our customers.

For all posts, we are legally obliged to confirm that the appointee is eligible to work in the UK before they start working for us. When applying for jobs it is important that you are aware of your eligibility status as government restrictions apply to the employment of migrant workers. If invited to interview, you will be required to provide proof of your eligibility to work in the UK on your arrival.

Due to the anticipated high number of applicants, we can only reply to candidates with the most relevant skills and experience. If you have not heard back from us within one month of submitting your application, please assume that you have been unsuccessful on this occasion.