Established since 2001, Domainex is a privately-owned, rapidly growing drug discovery therapeutics company with expertise spanning disease target expression, hit discovery, hit-to-lead identification and lead optimisation. We have established a reputation for a high-quality and innovative approach, and have a sustained track record of delivering preclinical drug candidates. Our clients include leading academic groups, biotechnology and pharmaceutical companies from the UK and overseas.
At an exciting stage in its evolution, Domainex has recently moved in to a newly refurbished facility on Chesterford Research Park, near Cambridge, giving an over two-fold increase in laboratory space. The company is now looking to welcome experienced and ambitious scientists to our team.
The Domainex team has been recruited from major companies and leading universities, and we are highly experienced in every aspect of drug discovery. Our state of the art laboratories are located near Cambridge, at the centre of Europe’s largest biotechnology cluster. We have a multi-disciplinary, collegiate culture where ideas, innovation, commitment and collaboration are encouraged.
- ADME/PK Scientist/Senior Scientist – Cambridge, UK
- Laboratory Technician - Cambridge, UK
- Analytical Chemist - Cambridge, UK
Domainex require an experienced ADME/PK ‘hands-on’ scientist to lead the delivery of high-quality ADME/PK assay data into client-focused drug discovery projects in a just-in-time manner. The role shall require the ability to design, develop, conduct, analyse and report on in vitro ADME/PK studies. This exciting role will require cross-team collaboration with bioassay scientists, analytical and medicinal chemists, utilizing established automation and informatics systems. It will span various therapeutic areas, with projects at differing stages of the drug discovery process. The candidate will also need to work with colleagues in sales and marketing to generate case studies, generate marketing literature and provide input during the proposal stage of new projects.
Qualified to BSc or PhD level, all applicants must have prior industrial experience of performing/interpreting in vitro assays; including, but not limited to, metabolic stability, metabolite identification, CYP inhibition, drug transporters, reaction phenotyping and protein binding. Our ideal candidates will have established skills in cell-based in vitro assays including hepatocyte turnover and Caco-2 cell permeation models as applied to drug absorption. Ideally a senior candidate would have the following experience; (i) hands-on experience of mass spectrometry as applied to in vitro drug metabolism (ii) hands-on experience of bioanalytical method development and metabolite identification using LC/MS/MS (and/or QTof).
An ability to work across multiple projects is required and ideal candidates must possess excellent organisation, planning, communication and data analysis skills. Senior candidates will be expected to influence drug discovery projects and provide data interpretation to our customers via written reports and/or face-to-face communication.
To apply, please send your CV and a covering letter, quoting reference AN0817, to firstname.lastname@example.org
Domainex is looking to recruit a laboratory technician. This hands-on position will be integral to the success of all our laboratory-based scientific work by ensuring that all laboratory housekeeping matters are dealt with smoothly and efficiently, enabling our scientists to focus on their research activities.
- Conducting regular stock checks and order of consumables, solvents and gas cylinders to maintain agreed stock levels.
- Receive deliveries, unpack and put away consumables. Deliver chemicals and biological samples to scientists who have ordered them. Organise support from scientists as required.
- Book-in deliveries on the procurement system, and file hard copies of shipping documents.
- Organise rota systems for scientists to assist you with receipt of deliveries, unpacking chemicals and consumables when needed. Anticipating peak demands and covering holidays and out of hour working.
- Coordinate regular chemical and biological waste disposals and be the point of contact.
- Liaise with and organise glassware repairs for laboratory equipment (as required).
- Load dirty (but decontaminated) scientific glassware into glass washers and put clean and dry glassware back in laboratory cupboards.
- Coordinate a rota for scientists to carry out the daily waste solvent disposal. (This solvent disposal is not anticipated to be a lab technician task).
- Monitor fume hood velocity performance weekly and notify facilities management if issues are identified.
- Prepare HPLC solvent mixtures.
- Prepare media and buffers for biology.
- Assist with shipments of materials to clients (book and track shipments, and assist with shipment packaging when your time permits).
- Laboratory coat management: Organise cleaning, ordering of new coats, and putting away of clean coats weekly.
- Check first aid boxes and eyewash bottles according to appropriate schedule, and arrange new supplies as required.
- Maintain records of equipment servicing and PAT testing across the laboratories.
Applicants do not need a science degree for this job, but will need to be able to think logically, perform arithmetic calculations, have excellent verbal and written communication skills, and must be able to manage and prioritise their time efficiently. As the jobholder will be an important member of the scientific team, candidates must be good team workers with the ability to work on their own when needed. They must also be willing to take instruction but be proactive and have the confidence to manage their own workload without guidance.
This is a new position following a recent expansion, so the successful applicant will be able to develop within the role. This is a five days per week position; hours are negotiable but will minimally be between 9am and 3.00pm.
Although previous experience would be advantageous, it is not essential as full training will be given: so if you fit the criteria and are new to the industry or looking for a career change, your application would be very welcome.
To apply, please send your CV and a covering letter, quoting reference LT2017, to email@example.com
Domainex currently has a full-time, permanent position available immediately for an analytical scientist. The role involves the development, qualification and implementation of analytical methods suitable for bioassay applications and also the characterisation of compounds for biological testing.
Our ideal candidate will have a minimum B.Sc/M.Sc. degree (in Chemistry or Analytical Chemistry) and industrial experience in an analytical chemistry laboratory. Experience in the operation of LC and preferably LCMS equipment, and proven LC method-development skills are essential.
An understanding of LCMS instrument maintenance and troubleshooting would be beneficial. It would be advantageous if you are skilled in the undertaking and analysis of MS-based bioanalytical methods, e.g. to assess compound ADME parameters. An ability to work across multiple projects is required and ideal candidate must possess excellent organisation, planning, communication and data analysis attributes. Practical knowledge of other techniques such as NMR, GCMS, preparative HPLC, would be desirable.
As a fast-growing technology company, Domainex offers a stimulating environment in which to work. Scientists are encouraged to be innovators, work collaboratively and above all to deliver high quality data and results to its customers.
To apply, please send your CV and a covering letter, quoting reference AC1117, to firstname.lastname@example.org
For all posts, we are legally obliged to confirm that the appointee is eligible to work in the UK before they start working for us. When applying for jobs it is important that you are aware of your eligibility status as government restrictions apply to the employment of migrant workers. If invited to interview, you will be required to provide proof of your eligibility to work in the UK on your arrival.
Due to the anticipated high number of applicants, we can only reply to candidates with the most relevant skills and experience. If you have not heard back from us within one month of submitting your application, please assume that you have been unsuccessful on this occasion.