Medicinal Chemistry
Design and synthesis from hits to candidate drugs
Our chemists have many years of experience in creating drug candidates from screening hits. Domainex will design a medicinal chemistry programme taking into account all the relevant factors including biological activity, drug-likeness, likelihood of toxicology, and patentability. The combination of thoughtful design with one-at-a-time synthesis and the preparation of intelligently designed arrays of compounds is integral to the way Domainex works, and allows faster provision of high-quality development candidates.
Key elements in the medicinal chemistry strategy will include:
- Experimental Design techniques to plan the synthesis of sets of analogues that will thoroughly explore structure-activity relationships
- Arrays of analogues that explore several areas of the molecule simultaneously
- Incorporating protein-ligand structural information (when available) into the compound and library designs
- Using pharmacophore hypotheses to drive our design process.
- Using predicted physicochemical parameters to design compounds
- Careful consideration of Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) properties of compounds throughout lead development
