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Domainex Drug Pipeline

Domainex is developing an oncology and autoimmune disease focussed pipeline of novel drug compounds. We have chosen a number of well-validated but challenging targets, that we have successfully unlocked with our Combinatorial Domain Hunting and LeadBuilder technologies.  The pipeline is focussed upon some exciting kinases and on lysine methyltransferases (KMTs) involved in epigenetics,

We intend to take these projects into lead optimization and candidate selection, and would welcome enquiries from collaborators who may be interested in working with us on their further development.



Target

Target
expression


Assay

Crystal Structure


Hit ID


H2L

Lead
Optimisation
Candidate
Drug
Nomination
TBK1/IKK╬Á Tick Tick   Tick Tick Tick 2014
KMT target 1 (G9a) Tick Tick Tick Tick Tick    
KMT target 2 (MLL2) Tick Tick Tick        
KMT target 3
Tick Tick   Tick      
KMT target 4 Tick            
KMT target 5 Tick