New drug discovery company Domainex and the leading global biopharmaceutical company UCB have successfully completed their first collaborative project with the creation of a particularly elusive target protein construct. Domainex used its Combinatorial Domain Hunting technology to identify a soluble and highly-expressed construct of a protein that had been refractory to other methods. This construct was then used by UCB to obtain a high-resolution crystal structure of the target protein with a proprietary inhibitor bound to the active site.
Mark Bushfield of UCB commented: “The construct provided by Domainex has all the characteristics that we were looking for, and I am sure this would not have been found using any other method. We are currently in discussions to agree the next stage of our collaboration".