Publications

Scientist at Domainex analyzing SDS PAGE gel

Scientific publications and trade articles from Domainex's highly experienced team and its collaborators:

Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design

Zhang et al., (September 2018), Mol. Pharmacol


Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Phillip S. Fallon et al., (August 2018), Nature Communications


Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells

Powell et al., (April 2018), J. Med. Chem.


New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

Vilaboa et al., (March 2017), Nucleic Acids Research


Evolving Catalytic Properties of the MLL Family SET Domain

Reid J, Reich S et al., (Oct 2015), Structure


Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

Elliott R, Ashley J et al., (Aug 2015), MedChemComm


The Discovery of a Highly Selective 5,6,7,8- Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model

Di Frusci et al., (Jan 2015), ChemMedChem 


The Discovery of Potent, Selective and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma

Newton G et al. (Nov 2014), J. Med. Chem.

Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors

Elizabeth H Donahue et al., (August 2014), BMC Microbiology


Disease-modifying treatment for COPD

Lloyd Dunlap (Jun 2014), Drug Discovery News


On the histone lysine methyltransferase activity of fungal metabolite chaetocin

Fanny L. Cherblanc, et al., (October 2013), J Med Chem


Nonhuman targets in allergic lung conditions

Robinson C et al., (Feb 2013), Future Medicinal Chemistry


Calling the X-MAN to battle cancer gene

Cirigliano J., (Sept 2012), Drug Discovery News


Putting a little structure in your drug design

McCudden J., (Jun 2012), Laboratory News


Giving Freedom of Expression to Drug Designers

Fallon P., (Jun 2012), Drug Discovery & Development


Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting

Meier C et al., (Feb 2012), J Struct Biol. 


A structural and functional dissection of the cardiac stress response factor MS1

Fogl et al., (Feb 2012), Proteins


Future inhaled drugs by virtual innovation: allergen delivery inhibitors

Robinson C et al., (2011), Future Med. Chem.


A combinatorial method to enable detailed investigation of protein-protein interactions

Maclagan K et al., (Mar 2011), Future Med. Chem.


Combinatorial Domain Hunting (CDH); a Novel Technique Identifies the Nature of the Interaction between NF-kB and C/EBP.

Khanjani, Shirin et al, (2011), Reproductive Sciences 


Overcoming Bottlenecks in drug discovery

Perrior T., (Fall 2010), Drug Discovery World


Combinatorial Domain Hunting: solving problems in protein expression

Littler E., (Jun 2010), Drug Discov Today


Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction

Jarvis A et al., (Mar 2010), J. Med. Chem.


(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0-2), and CO2CH2CH2OH: a new group of CO-releasing molecules.

Scapens, David et al., (Nov 2007), Dalton Transactions


Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications

Reich S et al., (Oct 2006), Protein Science