Publications

Scientist at Domainex analyzing SDS PAGE gel

Scientific publications and trade articles from Domainex's highly experienced team and its collaborators:

New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

Vilaboa et al., (March 2017), Nucleic Acids Research

Evolving Catalytic Properties of the MLL Family SET Domain

Reid J, Reich S et al., (Oct 2015), Structure

Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

Elliott R, Ashley J et al., (Aug 2015), MedChemComm

The Discovery of a Highly Selective 5,6,7,8- Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model

Di Frusci et al., (Jan 2015), ChemMedChem 

The Discovery of Potent, Selective and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma

Newton G et al. (Nov 2014), J. Med. Chem.

Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors

Elizabeth H Donahue et al., (August 2014), BMC Microbiology

Disease-modifying treatment for COPD

Lloyd Dunlap (Jun 2014), Drug Discovery News

On the histone lysine methyltransferase activity of fungal metabolite chaetocin

Fanny L. Cherblanc, et al., (October 2013), J Med Chem

Nonhuman targets in allergic lung conditions

Robinson C et al., (Feb 2013), Future Medicinal Chemistry

Calling the X-MAN to battle cancer gene

Cirigliano J., (Sept 2012), Drug Discovery News

Putting a little structure in your drug design

McCudden J., (Jun 2012), Laboratory News

Giving Freedom of Expression to Drug Designers

Fallon P., (Jun 2012), Drug Discovery & Development

Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting

Meier C et al., (Feb 2012), J Struct Biol. 

A structural and functional dissection of the cardiac stress response factor MS1

Fogl et al., (Feb 2012), Proteins

Future inhaled drugs by virtual innovation: allergen delivery inhibitors

Robinson C et al., (2011), Future Med. Chem.

A combinatorial method to enable detailed investigation of protein-protein interactions

Maclagan K et al., (Mar 2011), Future Med. Chem.

Combinatorial Domain Hunting (CDH); a Novel Technique Identifies the Nature of the Interaction between NF-kB and C/EBP.

Khanjani, Shirin et al, (2011), Reproductive Sciences 

Overcoming Bottlenecks in drug discovery

Perrior T., (Fall 2010), Drug Discovery World

Combinatorial Domain Hunting: solving problems in protein expression

Littler E., (Jun 2010), Drug Discov Today

Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction

Jarvis A et al., (Mar 2010), J. Med. Chem.

(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0-2), and CO2CH2CH2OH: a new group of CO-releasing molecules.

Scapens, David et al., (Nov 2007), Dalton Transactions

Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications

Reich S et al., (Oct 2006), Protein Science