Publications

Scientist at Domainex analyzing SDS PAGE gel

Scientific publications and trade articles from Domainex's highly experienced team and its collaborators:

Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens

Jihui Zhang, Jie Chen, Jie Zuo, Gary K. Newton, Mark R. Stewart, Trevor R. Perrior, David R.Garrod and Clive Robinson; (October 2018), Int. J. Mol. Sci.


Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design

Jihui Zhang, Jie Chen, Gary K. Newton, Trevor R. Perrior, and Clive Robinson., (September 2018), Mol. Pharmacol


Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Camilo E. Quevedo, Abimael Cruz-Migoni, Nicolas Bery, Ami Miller, Tomoyuki Tanaka, Donna Petch, Carole J.R. Bataille, Lydia Y.W. Lee, Phillip S. Fallon, Hanna Tulmin, Matthias T. Ehebauer, Narcis Fernandez-Fuentes, Angela J. Russell, Stephen B. Carr, Simon E.V. Phillips and Terence H. Rabbitts., (August 2018), Nature Communications


Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells

Jonathan Powell, Filipa Mota, David Steadman, Christelle Soudy, Jeremy T. Miyauchi, Stuart Crosby, Ashley Jarvis, Tifelle Reisinger, Natalie Winfield, Graham Evans, Aled Finniear, Tamas Yelland, Yi-Tai Chou, A.W. Edith Chan, Andrew O’Leary, Lili Cheng, Dan Liu, Constantina Fotinou, Carla Milagre, John F. Martin, Haiyan Jia, Paul Frankel, Snezana Djordjevic, Stella E. Tsirka, Ian C Zachary and David L. Selwood., (April 2018), J. Med. Chem.


New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival

Nuria Vilaboa, Alba Bor´e, Francisco Martin-Saavedra, Melanie Bayford, Natalie Winfield, Stuart Firth-Clark, Stewart B. Kirton and Richard Voellmy., (March 2017), Nucleic Acids Research


Evolving Catalytic Properties of the MLL Family SET Domain

Ying Zhang, Anshumali Mittal, James Reid, Stephanie Reich, Steven J. Gamblin and Jon R. Wilson., (Oct 2015), Structure


Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

Richard J. R. Elliott, Ashley Jarvis, Mohan B. Rajasekaran, Malini Menon, Leandra Bowers, Ray Boffey, Melanie Bayford, Stuart Firth-Clark, Rebekah Key, Rehan Aqil, Stewart B. Kirton, Dan Niculescu-Duvaz, Laura Fish, Filipa Lopes, Robert McLeary, Ines Trindade, Elisenda Vendrell, Felix Munkonge, Rod Porter, Trevor Perrior, Caroline Springer, Antony W. Oliver, Laurence H. Pearl, Alan Ashworth and Christopher J. Lord., (Aug 2015), MedChemComm


The Discovery of a Highly Selective 5,6,7,8- Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model

Dr. Paolo Di Fruscia, Emmanouil Zacharioudakis, Chang Liu, Dr. Sébastien Moniot, Sasiwan, Laohasinnarong, Mattaka Khongkow, Ian F. Harrison, Konstantina Koltsida, Dr. Christopher R. Reynolds, Karin Schmidtkunz, Prof. Dr. Manfred Jung, Dr. Kathryn L. Chapman, Prof. Dr. Clemens Steegborn, Prof. David T. Dexter, Prof. Michael J. E. Sternberg, Prof. Eric W.F. Lam and Dr. Matthew J. Fuchter., (Jan 2015), ChemMedChem 


The Discovery of Potent, Selective and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma

Gary K. Newton, Trevor R. Perrior, Kerry Jenkins, Meriel R. Major, Rebekah E. Key, Mark R. Stewart, Stuart Firth-Clark, Steven M. Lloyd, Jihui Zhang, Nicola J. Francis-Newton, Jonathan P. Richardson, Jie Chen, Pei Lai, David R. Garrod and Clive Robinson., (Nov 2014), J. Med. Chem.


Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors

Elizabeth H Donahue, Lisa F Dawson, Esmeralda Valiente, Stuart Firth-Clark, Meriel R Major, Eddy Littler, Trevor R Perrior and Brendan W Wren., (August 2014), BMC Microbiology


On the histone lysine methyltransferase activity of fungal metabolite chaetocin

Fanny L. Cherblanc, Kathryn Chapman, Jim Reid, Aaron Borg, Sandeep Sundriyal, Laura Alcazar Fuoli, Elaine Bignell, Marina Demetriades, Christopher J. Schofield, Peter DiMaggio, Robert Brown, and Matthew J Fuchter., (October 2013), J Med Chem


Nonhuman targets in allergic lung conditions

Clive Robinson, Jihui Zhang, Gary K Newton and Trevor R Perrior., (Feb 2013), Future Medicinal Chemistry


Giving Freedom of Expression to Drug Designers

Fallon P., (Jun 2012), Drug Discovery & Development


Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting

Christoph Meier, Daniel C. Brookings, Thomas A. Ceska, Carl Doyle, Haiping Gong, David McMillan, Giles P. Saville, Adeel Mushtaq, David Knight, Stefanie Reich, Laurence H. Pearl, Keith A. Powell, Renos Savva, Rodger A. Allen., (Feb 2012), J Struct Biol. 


A combinatorial method to enable detailed investigation of protein-protein interactions

Kate Maclagan, Rita Tommasi, Emmanuelle Laurine, Chrisostomos Prodromou, Paul C Driscoll, Laurence H Pearl, Stefanie Reich and Renos Savva., (Mar 2011), Future Med. Chem.


Combinatorial Domain Hunting: solving problems in protein expression

Littler E., (Jun 2010), Drug Discov Today


Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction

Ashley Jarvis, Charles K. Allerston, Haiyan Jia, Birger Herzog, Acely Garza-Garcia, Natalie Winfield, Katie Ellard, Rehan Aqil, Rosemary Lynch, Chris Chapman, Basil Hartzoulakis, James Nally, Mark Stewart, Lili Cheng, Malini Menon, Michelle Tickner, Snezana Djordjevic, Paul C. Driscoll, Ian Zachary and David L. Selwood., (Mar 2010), J. Med. Chem.


(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0-2), and CO2CH2CH2OH: a new group of CO-releasing molecules.

David Scapens, Harry Adams, Tony R. Johnson, Brian E. Mann, Philip Sawle, Rehan Aqil, Trevor Perrior and Roberto Motterlini., (Nov 2007), Dalton Transactions


Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications

Stefanie Reich,Loretto H. Puckey, Caroline L. Cheetham, Richard Harris, Ammar A.E. Ali, Uma Bhattacharyya, Kate Maclagan, Keith A. Powell, Chrisostomos Prodromou, Laurence H. Pearl, Paul C. Driscoll and Reno Savva., (Oct 2006), Protein Science