Scientific publications and trade articles from Domainex's highly experienced team and its collaborators:
Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design
Zhang et al., (September 2018), Mol. Pharmacol
Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment
Phillip S. Fallon et al., (August 2018), Nature Communications
Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells
Powell et al., (April 2018), J. Med. Chem.
New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival
Vilaboa et al., (March 2017), Nucleic Acids Research
Reid J, Reich S et al., (Oct 2015), Structure
Elliott R, Ashley J et al., (Aug 2015), MedChemComm
The Discovery of a Highly Selective 5,6,7,8- Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model
Di Frusci et al., (Jan 2015), ChemMedChem
The Discovery of Potent, Selective and Reversible Inhibitors of the House Dust Mite Peptidase Allergen Der p 1: An Innovative Approach to the Treatment of Allergic Asthma
Newton G et al. (Nov 2014), J. Med. Chem.
Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors
Elizabeth H Donahue et al., (August 2014), BMC Microbiology
Fanny L. Cherblanc, et al., (October 2013), J Med Chem
Robinson C et al., (Feb 2013), Future Medicinal Chemistry
Fallon P., (Jun 2012), Drug Discovery & Development
Meier C et al., (Feb 2012), J Struct Biol.
Fogl et al., (Feb 2012), Proteins
Maclagan K et al., (Mar 2011), Future Med. Chem.
Combinatorial Domain Hunting (CDH); a Novel Technique Identifies the Nature of the Interaction between NF-kB and C/EBP.
Khanjani, Shirin et al, (2011), Reproductive Sciences
Littler E., (Jun 2010), Drug Discov Today
Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction
Jarvis A et al., (Mar 2010), J. Med. Chem.
(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0-2), and CO2CH2CH2OH: a new group of CO-releasing molecules.
Scapens, David et al., (Nov 2007), Dalton Transactions
Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications
Reich S et al., (Oct 2006), Protein Science