Discovering a Galaxy of Opportunity - Unleashing the power of plate-based chemistry combined with rapid screening
Unleash the full potential of our D2B expertise on your drug discovery project. Whether it’s to enable your Targeted Protein Degrader (TPD) project or supercharge your hit-to-lead (H2L) or lead optimisation (LO) programmes, Direct-to-Biology will open up a galaxy of opportunity for you! So, partner with Domainex and revolutionise your drug development process today.
Benefits of Direct-to-Biology (D2B) in Drug Discovery
Drug discovery is a complex and time-consuming process that requires the seamless integration of multiple disciplines and technologies. D2B has revolutionised the field by combining ‘plate-based chemistry’ with rapid biological screening. The key benefits of employing Domainex’s D2B expertise in your integrated drug discovery project include:
Expert compound library design
Computational design to increase chemical diversity
Molecular modelling and in silico property predictions
Assessment of scaffolds for plate-based chemistry
Accelerated compound synthesis
For TPD projects: In-house ‘toolbox’ of partial PROTACs available for immediate reaction with protein of interest (POI) binders
Efficient resource allocation
Miniaturisation of reactions - Enhances efficiency and reduces environmental impact
Up to 380 compounds can be generated in a single plate and screened using the workflow below:
Plate-based reaction optimisation is undertaken prior to D2B to ensure workflow efficiency and to minimise reagent usage.
Utilising this process, 1,000s of compounds can be synthesised and screened in less than 1 month
Automated QC and analysis, using UPLC MS, is conducted to allow a heat-map overview to be produced to assess the quality of each plate (see Figure 1)
Hits can be observed even when a relatively low sample purity is observed.
D2B combines plate-based chemistry with rapid screening, synergistically enhancing the efficiency and success of drug discovery. These methods allow researchers to explore rapidly chemical space, identify hits, validate their biological activity, gain early insights into mechanism of action and asses the ADME properties, ultimately streamlining the development of novel and effective therapeutics. By embracing these cutting-edge techniques, Domainex will accelerate your drug discovery programmes and help you to bring life-changing medicines to patients more efficiently and effectively.
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Unleash the full potential of our D2B expertise on your drug discovery project. Whether it’s to enable your Targeted Protein Degrader project or supercharge your hit-to-lead or lead optimisation programmes, Direct-to-Biology will open up a galaxy of opportunity for you!