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PROTAC Platform: Enabling Rapid Design, Characterisation and Assessment

Posters

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Newsletters

Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications

Publications

Identification of novel hit chemotypes by covalent fragment screening and binding site identification using proteolytic digestion and high-resolution LCMS

Posters

Domainex Q3 2023 Newsletter - International and UK growth lead to exciting expansion plans for Domainex

Newsletters

Detergent-free purification of membrane proteins using PoLiPa technology for Cryo-EM

Posters

Identification of covalent fragment binding sites by proteolytic digestion and High-Resolution LCMS

Posters

The Novel DNA Binding Mechanism of Ridinilazole, a Precision Clostridiodes difficile Antibiotic

Publications

Integrated Drug Discovery for CNS Targets

Brochures

Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications

Publications

Domainex Q1 2023 Newsletter - Awards success recognises strength in people & partnerships

Newsletters

Integrated Ion Channel Drug Discovery

Brochures

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Domainex
  • About
    • About
    • Track Record
    • Case Studies
    • Testimonials
    • Awards
    • Management team
    • Board members
    • Investors
    • Contact us
  • Services
    • Offerings
      • ADME and Bioanalytical Sciences
      • Analytical Chemistry
      • Assay Development
      • Biochemical Assays
      • Biophysical Assays
      • Cell Based Assays
      • Computational Chemistry
      • Fragment and Compound Screening
      • Integrated Drug Discovery Services
      • Medicinal Chemistry
      • Protein Expression and Purification Services
      • Structural Biology
      • Synthetic Chemistry
      • Virtual screening
    • Research Phases
      • Hit Identification
      • Hit to Lead
      • Lead Optimisation
    • Therapeutic Areas
      • Anti-infectives
      • Cardiovascular
      • CNS Drug Discovery
      • Immuno-Oncology
      • Inflammatory diseases
      • Oncology
      • Respiratory
    • Target Classes
      • GPCRs
      • Ion Channels
      • Kinases
      • Methyltransferases
      • Proteases
      • Protein-Protein Interactions
      • Targeted Protein Degradation
    • Approaches & Techniques
      • CDH (Target Gene Fragmentation)
      • Cryogenic Electron Microscopy (Cryo-EM)
      • Differential Scanning Fluorimetry (DSF) and nanoDSF Services
      • Flow Cytometry
      • Fragment Based Drug Discovery (FBDD)
      • FragmentBuilder
      • Grating-Coupled Interferometry
      • High Throughput Screening
      • Isothermal Titration Calorimetry (ITC)
      • LeadBuilder
      • MicroScale Thermophoresis (MST) Services
      • PoLiPa (Membrane Protein Solubilisation)
      • Structure Based Drug Design (SBDD)
      • Surface Plasmon Resonance (SPR)
      • X-ray Crystallography
  • Library
    • Articles
    • Brochures
    • Newsletters
    • Posters
    • Presentations & Videos
    • Publications
    • White Papers
  • News & Events
  • Careers

+44(0) 1223 433180 enquiries@domainex.co.uk

Offerings

  • Fragment and Compound Screening
  • Cell Based Assays
  • Medicinal Chemistry
  • Synthetic Chemistry
  • Computational Chemistry
  • Analytical Chemistry
  • ADME and Bioanalytical Sciences
  • Protein Expression and Purification Services
  • Structural Biology
  • Biochemical Assays
  • Biophysical Assays
  • Assay Development

Research Phases

  • Lead Optimisation
  • Hit to Lead
  • Hit Identification

Therapeutic Areas

  • Anti-infectives
  • Inflammatory diseases
  • CNS Drug Discovery
  • Oncology
  • Immuno-Oncology
  • Cardiovascular
  • Respiratory Disease

Target Classes

  • Ion Channels
  • Protein-Protein Interactions
  • Targeted Protein Degradation
  • Kinases
  • GPCRs
  • Proteases
  • Protein Methyltransferases

Approaches & Techniques

  • Innovative Polymer Lipid Particle (PoLiPa) Technology
  • Structure Based Drug Design (SBDD)
  • Ligand binding assays by Surface Plasmon Resonance (SPR) and/or Grating-Coupled Interferometry (GCI)
  • MicroScale Thermophoresis (MST) Services
  • Differential Scanning Fluorimetry (DSF) and nanoDSF Services
  • High Throughput Screening
  • Cryogenic Electron Microscopy (Cryo-EM)
  • X-ray Crystallography
  • Flow Cytometry
  • CDH (Target Gene Fragmentation)
  • Isothermal Titration Calorimetry (ITC)
  • LeadBuilder – Virtual Screening
  • FragmentBuilder: Fragment-Based Drug Discovery and Design

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