Membrane protein production

Our protein scientists have optimised a screening platform to identify the best approach to purify your membrane protein, whether that is a detergent-based or detergent-free strategy.

Membrane proteins such as ion channels, GPCRs and transporters are key targets for drug discovery. The transmembrane regions of such proteins interact directly with the membrane phospholipid bilayer, enabling them to perform tasks such as transporting ions and small molecules, or relaying signals from extracellular stimuli to the internal environment of the cell. 

Despite the prominent role played by membrane proteins in multiple disease modalities, membrane protein drug discovery remains challenging. Extraction of membrane proteins is critical to elucidating their structural and functional roles within complex biological systems. However, their localisation and the hydrophobic nature of transmembrane regions presents unique challenges in purifying correctly folded and functional protein samples for use in drug discovery. Our experienced team can support all aspects of your membrane protein programme from protein expression and purification, atomic structure determination, compound design and synthesis, through to cell-based and biophysical screening.