Structural Biology

High-resolution protein structures to progress your drug discovery programme

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It is increasingly the case that our clients regard structure-based drug design (SBDD) as a vital component of their projects. Domainex has been a long-standing and a leading proponent of SBDD, so it’s not surprising that we have a strong in-house team of structural biologists including expert X-ray crystallographers, cryogenic electron microscopists and molecular modellers.

We can obtain high-resolution datasets for your target proteins (apo or ligand-bound) and process this data to solve the structures and present them to you in a variety of formats suitable for computational modelling.

X-ray crystallography is currently the gold-standard in terms of protein/protein-ligand structure generation. However, Cryo-EM is the method of choice for large proteins or protein complexes particularly when crystallisation has proved challenging. A combination of Cryo-EM and X-ray crystallography can be useful when resolution is limiting, fitting small X-ray structures into Cryo-EM density. Our experts will discuss your needs and recommend the right approach for your project.

Find out more about:

Protein Supply

Our highly skilled protein science team can prepare high-quality proteins using various expression systems, to support your structural studies, if required.


By coupling our structural biology know-how to our capabilities in fragment and structure-based drug design, you can access our state-of-the-art approaches to rapid compound optimisation. Our medicinal chemistry, bioanalytical chemistry and computational chemistry teams are skilled in the use of this invaluable information throughout the drug discovery process to optimise ligand design, assess any off-target liabilities and produce the most effective candidate molecules.

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