Careers

Join our highly qualified and experienced team

Domainex is a well-respected integrated medicines research services partner working globally with ambitious life science organisations, including biotechnology and pharmaceutical companies, patient foundations and academic institutes.

Domainex is a fast-growing, privately-owned drug discovery service company, with a strong reputation for innovation. We support academic, biotechnology, patient foundation and pharmaceutical life-science organisations globally to progress their drug discovery programmes towards pre-clinical development. We are an ambitious organisation offering best-in-class services to our sponsors. We are based at a state-of-the-art 20,000 square-foot facility at the Chesterford Research Park near Cambridge, UK and are a co-located, multi-disciplinary team of chemists and biologists with a friendly, collaborative, can-do approach to our work.

Complementing an ambitious growth strategy, we are actively investing in our people and technologies, and looking to strengthen our teams.  If you would like to join us, and have the skills and experience we are looking for, we would love to hear from you.​

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Analytical /Bioanalytical Group Leader/Head of Function

Applications are invited from talented and experienced analytical chemists with prior experience of line management for the role of Analytical/Bioanalytical group leader.  You will hold a PhD or a BSc/MSc degree in chemistry or natural sciences, supported by a proven track record and delivery of projects to assist in the drug discovery projects across hit identification, hit-to-lead and lead optimisation projects in large pharma, biotech or CRO sectors.  You will have an extensive knowledge of analytical chemistry and bioanalytical project support. A thorough understanding of DMPK and biology concepts would be advantageous in order to make key decisions for multidisciplinary drug discovery project teams. The role will involve significant interaction with external customers and the successful candidate will have excellent communication and inter-personal skills along with the ability to clearly summarise and present scientific results and ideas.

As this is a leadership position, previous experience of management of teams or groups is essential along with demonstrable experience of working with cross-discipline teams to successfully drive drug discovery projects. The remit of the role will be to expand the department, however, in the short term the role will require a degree of ‘hands-on’ relevant experience.

Main Roles and Responsibilities

  • Line-manage analytical and bioanalytical scientist of varying experience levels to deliver client projects and provision of expert analytical chemistry support to the medicinal chemistry team (currently 40 chemists)
  • Working with several clients to agree and implement project strategy and responsibility for the day-to-day reporting and communication of project progress to the clients
  • Providing leadership to multi-disciplinary project teams and provision of insight to the future project direction
  • Support the business development team to assist in securing new business for Domainex
  • Play a key role in the growth of the analytical and bioanalytical team
  • Play an active role as a member of the chemistry leadership team, using your knowledge to contribute to growing the department and influencing R&D strategy

If you would like to apply for this position, please send your CV and a covering letter, quoting reference ANGL0421 to recruitment2021@domainex.co.uk.

Closing Date: 20 December 2021, Please Note: This job post will be closed as soon as sufficient applicants have been received.


Analytical/Bioanalytical/ADME scientists (all levels including Team Leader)

Domainex has vacancies for talented laboratory-based analytical/bioanalytical chemists who are qualified to PhD or with BSc/MSc level in chemistry, life sciences or biochemistry with post-graduate analytical industry experience to support analysis and purification of synthetic molecules and bioanalysis from in vitro ADME studies.   The successful candidate will be required to demonstrate a thorough knowledge of analytical method and assay development, have hands-on experience of mass spectrometry and handling of microtitre plate-based samples.

The level of appointment will be commensurate with experience.  In addition to proven analytical skills, Domainex is particularly interested in hearing from applicants with experience in mammalian cell culture and protein analysis.  For consideration as a Team Leader, candidates must also have proven project management experience and prior supervisory/line management experience and perspectives on process enhancement. 

Main Roles and Responsibilities

  • Analytical assay development and delivery of results where your conclusions will guide projects
  • Contribute to the selection of bioanalytical assays to further clients mechanistic understanding for their projects
  • Support routine laboratory operation and maintenance
  • Prepare and present oral and written reports on research activities to internal and external audiences
  • Actively pursue own personal development
  • Line management opportunities
  • Maintain appropriate awareness of safety procedures, attend required safety training and adhere to laboratory safety rules as defined by the host department
  • Ensure that all duties are performed in accordance with organisational standards, policies and procedures
  • For team leader role: Report directly on your team’s performance to external clients and to the Domainex chemistry management team

If you would like to apply for one of these positions, please send your CV and a covering letter, quoting reference ABA0221 to recruitment2021@domainex.co.uk.

Closing Date: 20 December 2021, Please Note: These job postings will be closed as soon as sufficient applicants have been received.


Computational Chemist

Domainex has one position available for an experienced computational chemist during an exciting time as a we embark upon significant enhancement of our CADD capabilities.   The ideal candidate will be qualified to PhD level or a B.Sc/M.Sc. degree in a life science and be highly-skilled in small-molecule and protein modelling and chemoinformatics approaches applicable to drug discovery.  Experience in an industrial drug-discovery setting is strongly preferred.  Applicants should have hands on experience of applying a wide range of computational tools and techniques, including structure based and ligand-based design and virtual screening.  This role will operate a cross-discipline matrix environment and a knowledge of drug discovery processes and appreciation of key concepts from collaborating disciplines such as medicinal chemistry and biophysics is essential.

Main Roles and Responsibilities

  • Application of problem-solving ability through a combination of personal knowledge of computational techniques with the desire to seek-out and apply novel and innovative solutions from the wider literature to help progress customer projects
  • Run virtual screening (both structure and ligand-based) and select compounds for purchase
  • Support on-going hit discovery and lead-optimisation projects
  • Influence and aid the further development of our computational chemistry and capabilities
  • Work alongside the business development team to identify and secure new opportunities and contribute to the preparation of scientific proposals

If you would like to apply for this position, please send your CV and a covering letter, quoting Reference: CC0221 to recruitment2021@domainex.co.uk

Closing Date: 20 December 2021, Please Note: This job post will be closed as soon as sufficient applicants have been received.


Medicinal Chemistry Group Leader 

Applications are invited from talented and experienced medicinal chemists with prior experience of line management for the role of medicinal chemistry group leader.  You will hold a Ph.D. or a B.Sc/M.Sc. degree in organic or medicinal chemistry supported by a proven track record and delivery across hit identification, hit-to-lead and lead optimisation projects in large pharma or the biotech sector.  You will have an extensive knowledge of synthetic and medicinal chemistry and a thorough understanding of DMPK, toxicology and biology concepts in order to make key decisions for drug design. The role will involve significant interaction with external customers and will require excellent communication, good inter-personal skills and the ability to clearly summarise and present scientific results and ideas.

As this is a leadership position, previous experience of management of teams or groups is essential along with demonstrable experience of working with cross-discipline teams to successfully drive drug discovery projects.

Main Roles and Responsibilities

  • Line-manage medicinal chemistry team leaders and medicinal chemists of varying experience levels
  • Working with several clients to agree and implement project strategy and responsibility for the day-to-day reporting and communication of project progress to the clients
  • Providing leadership to multi-disciplinary project teams provision of insight to the future chemistry direction for the project
  • Provision of chemistry expertise to the business development team to assist in securing new business for Domainex
  • Play an active role as a member of the chemistry leadership team, using your knowledge to contribute to growing the department and influencing R&D strategy

If you would like to apply for this position, please send your CV and a covering letter, quoting Reference: GL0221 to recruitment2021@domainex.co.uk

Closing Date: 20 December 2021, Please Note: This job post will be closed as soon as sufficient applicants have been received.


Cell Biologist / Assay biologist 

Domainex has a vacancy for a laboratory-based PhD level scientist (or BSc/MSc with relevant post-graduate experience) qualified in a biological discipline, with working experience in cell biology, biochemistry and/or biophysics fields.  The level of appointment will be commensurate with experience.

The ideal candidate will have practical experience with a range of screening techniques across cell biology or biochemical methods in microtitre plate format (e.g. cell viability assays, ELISAs, fluorescence polarisation).  Experience with isolated PBMCs would be an advantage. The post also requires an individual with a sound knowledge of molecular pharmacology; however, additional training will be provided to broaden your skill set.  The successful candidate will be enthusiastic, a quick learner, have good problem-solving skills, and be able to work effectively in a team. Candidates that have experience of preparing technical proposals and have a track record of building and deploying assay systems are particularly sought.   

Main Roles and Responsibilities

  • Apply cutting edge cell biological and/or biochemical techniques for lead discovery and lead optimisation for client projects.
  • Responsibility for developing and performing cell-based and biochemical assays (e.g. Fluorescence/FRET techniques, fluorescence polarisation, alphaLISA assays, phenotypic assays, proliferation assays, ELISA, western blots
  • Support routine laboratory operation and maintenance
  • Prepare and present oral and written reports on research activities to internal and external audiences
  • Actively pursue own personal development
  • Maintain appropriate awareness of safety procedures, attend required safety training and adhere to laboratory safety rules as defined by the host department
  • Ensure that all duties are performed in accordance with organisational standards, policies and procedures

To apply, please sending your CV, quoting reference AB0621, to recruitment2021@domainex.co.uk

Closing Date: 20 December 2021, Please Note: This job post will be closed as soon as sufficient applicants have been received.


Synthetic and Medicinal Chemist (all levels including team leaders)

Looking for the chance to use your scientific knowledge, to work alongside experienced researchers and contribute to the discovery of new treatments for patients? 

Domainex currently has opportunities for talented synthetic and medicinal chemistry laboratory-based scientists at all levels of experience including team leaders (project leaders) to join our research team. We’re an expanding contract research organisation (CRO) providing fully integrated, drug discovery services to the scientific community.  Our multi-disciplinary team works in a highly collaborative manner with our clients - bringing together talent, creativity and expertise to convert ideas and discoveries into new healthcare solutions.  Each client project brings new scientific challenges and our scientists must be versatile, and responsive to the evolving needs as each project progresses.

You may be involved in a range of synthetic projects and in Hit Identification, Hit-to-Lead, or Lead Optimisation programmes.

The successful candidates will have:

  • a Ph.D. in organic or medicinal chemistry, or a B.Sc/M.Sc. degree in chemistry and may also have additional experience in industry
  • a passion for synthetic chemistry and be able propose and execute synthetic routes efficiently
  • problem-solving ability from combining personal knowledge of synthetic methods and techniques, with the desire to seek-out and apply novel and innovative solutions from the wider literature
  • good communication skills; able to summarise and present scientific results and ideas to colleagues
  • excellent inter-personal skills
  • proven ability to work in a team, be proactive, and strive to deliver high quality

An ideal candidate will also have experience in some of the following areas:

  • experience in industry, with a proven track record
  • knowledge of DMPK, toxicology and biology concepts in order to make key decisions for drug design

Domainex is an award-winning company located in Cambridge, one of the UK’s leading hubs for bioscientific research and innovation, and offers a stimulating and rewarding research environment.

We currently have permanent opportunities available.  

If you would like to apply for one of these positions, please send your CV and a covering letter, quoting reference MSC1021 to recruitment2021@domainex.co.uk.

Please note: We are not accepting any enquiries or candidate profiles from recruitment organisations.

Closing Date: 30 November 2021


Analytical Chemists

Looking for the chance to use your scientific knowledge, to work alongside experienced researchers and contribute to the discovery of new treatments for patients? 

Domainex currently has opportunities for a talented analytical scientist to join our research team. We’re an expanding contract research organisation (CRO) providing fully integrated drug discovery services to the scientific community.  Our multi-disciplinary team works in a highly collaborative manner with our clients - bringing talent, creativity and expertise that converts ideas and discoveries into new healthcare solutions.  Each project brings new scientific challenges, and our scientists must be versatile and responsive to the evolving needs as each project progresses.

As an analytical scientist, you will be responsible for working with an established internal team to solve problems and deliver results for client projects.  A key element for this role this to support the growing chemistry department of currently 40 synthetic and medicinal chemists to maintain and repair Waters mass spectrometers, mass directed preparative instruments and to assist with challenging purification and chiral analysis/separation. Experience in this area is ideal, however, training will be given for candidates that have been identified with the appropriate technical skills to maintain and repair equipment.

In addition you will be part of an expanding analytical/bioanalytical team and will work at the interface between chemistry and biology, analysing samples prepared from a variety of biological matrices.  You will contribute to several different projects, across the whole drug discovery spectrum from Hit Identification to Lead Optimisation.  

The successful analytical/bioanalytical candidate will have:

  • M.Sc/ B.Sc/ degree in chemistry, natural sciences, or biochemistry.
  • Technically astute with problem-solving ability
  • Excellent inter-personal skills and proven ability to work in a team
  • Good communication skills; able to summarise and present scientific results and ideas to colleagues and external clients or collaborators as required
  • a proactive attitude, and strives to deliver high quality science

An ideal candidate will also have experience in some of the following areas:

  • Scientific instrument maintenance
  • LCMS, UPLC and MS/MS
  • HPLC,
  • NMR analysis

Domainex is an award-winning company located in Cambridge, one of the UK’s leading hubs for bioscientific research and innovation, and offers a stimulating and rewarding research environment.

If you would like to apply for one of these positions, please send your CV and a covering letter, quoting reference AC1121 to recruitment2021@domainex.co.uk.

Please note: We are not accepting any enquiries or candidate profiles from recruitment organisations.

Closing Date: 20 December 2021


Laboratory and Facilities Manager 

Due to expansion of our operation, Domainex is seeking a Laboratory and Facilities Manager.  The successful applicant will be responsible for the smooth day-to-day running of laboratory operations and co-ordination of maintenance contractors for both building operations and laboratory equipment at our Chesterford Research Park laboratories. We are housed in a 20,000 square foot facility made up of chemistry and biology labs.  There will also be the requirement to manage a satellite site in the Cambridge area.

Central to the role will be interacting with staff at all levels, up to and including CEO, to oversee the smooth and efficient performance of all laboratories through ensuring appropriately stocked laboratory supplies, coordinating the work of facilities contractors and arranging and co-ordinating external equipment maintenance contractors. The role will also include the management of laboratory technicians providing laboratory-based support to the scientific teams.

We are seeking a highly organised individual with previous experience gained from the life science sector bringing good knowledge of supporting a large team of laboratory-based scientists, underpinned by effective delivery of facility management, procurement practices, shipping internationally and working with a variety of high-tech vendors. Our successful applicant will be expected to have strong people-oriented skills and have an ability to communicate effectively with both scientists and non-scientists.  An aptitude to identify and implement efficient working practices is required. Experience of overseeing facility maintenance with a set of contractors will be required as will the ability to operate within an allocated budget.

This will be a full time, on-site role, predominantly based at Chesterford Research Park.

Main Roles and Responsibilities

Day-to-day co-ordination of operations required to maintain business operations including waste collection, cleaning etc. and ensuring compliance with H&S regulations with appropriate guidance

Ensure stock levels of common reagents and consumables are appropriately stocked and levels maintained

Handling Goods-in and -out and a good knowledge of shipping procedures and import and export requirements

Co-ordinating and negotiating with suppliers for preferential pricing for capital expenditure items

Arranging for routine servicing and repair of laboratory equipment, including negotiation and collation of service contracts.

Management of building activities to comply with H&S legislation, including fire alarm, legionella and portable appliance testing

Managing a schedule for emergency and preventative building maintenance and the identification and co-ordinator of contractors to undertake such works.

For all posts, we are legally obliged to confirm that the appointee is eligible to work in the UK before they start working for us. When applying for jobs it is important that you are aware of your eligibility status as government restrictions apply to the employment of migrant workers.  If invited to interview, you will be required to provide proof of your eligibility to work in the UK on your arrival.

For all positions please email your CV and a covering letter to recruitment2021@domainex.co.uk quoting the Job Reference number FM1121

Closing date for applications: 3rd December 2021

 


Established in 2001, Domainex is a privately-owned, rapidly growing drug discovery services company with expertise spanning disease target expression, hit discovery, hit-to-lead identification and lead optimisation.

We have established an excellent reputation for providing high-quality and innovative drug discovery services and have an established track record of delivering preclinical drug candidates for our partners. Our clients include leading universities, biotechnology and pharmaceutical companies in the UK and overseas.

As a fast-growing technology company, Domainex offers a stimulating environment in which to work. Scientists are encouraged to be innovators, work collaboratively and above all to deliver high quality data and results to our customers.

For all roles, the successful candidate will have good attention to detail and high scientific standards and be able to demonstrate an enthusiasm for their chosen discipline and the broader field of drug discovery.  As an organisation, Domainex prides itself on providing innovative solutions to challenging problems, requiring a curiosity and desire to seek-out and apply novel and innovative solutions from the wider literature to progress Domainex’s customer projects and enhance our internal capabilities.  All roles will require regular interaction with new and existing customers requiring candidates to have well developed communication and inter-personal skills.  Domainex will provide opportunity and support to develop both scientific and personal skills further, as well as exposure to the project management skills and business acumen required to maintain a successful and growing CRO organisation. 

For all posts, we are legally obliged to confirm that the appointee is eligible to work in the UK before they start working for us. When applying for jobs it is important that you are aware of your eligibility status as government restrictions apply to the employment of migrant workers.  If invited to interview, you will be required to provide proof of your eligibility to work in the UK on your arrival.

For all positions please email your CV and a covering letter to recruitment2021@domainex.co.uk quoting the Job Reference number.

Due to the anticipated high number of applicants, we can only reply to candidates with the most relevant skills and experience. If you have not heard back from us within one month of submitting your application, please assume that you have been unsuccessful on this occasion.

Domainex is not accepting unsolicited assistance from search firms for any employment opportunities. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Domainex via email, the Internet or in any form and/or method without a valid written search agreement in place for any position will be deemed the sole property of Domainex. No fee will be paid in the event the candidate is hired by Domainex as a result of the referral or through other means.