Careers

Join our highly qualified and experienced team

Domainex is a well-respected integrated medicines research services partner working globally with ambitious life science organisations, including biotechnology and pharmaceutical companies, patient foundations and academic institutes.

Domainex is a fast-growing, privately-owned drug discovery service company, with a strong reputation for innovation. We support academic, biotechnology, patient foundation and pharmaceutical life-science organisations globally to progress their drug discovery programmes towards pre-clinical development. We are an ambitious organisation offering best-in-class services to our sponsors. We value our members of staff and foster an environment of continuous improvement and learning. To find out more about Domainex's training programme, click here to read our recent blog.

Complementing an ambitious growth strategy, we are actively investing in our people and technologies, and looking to strengthen our teams.  If you would like to join us, and have the skills and experience we are looking for, we would love to hear from you.​

 

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Analytical/Bioanalytical/ADME scientists (all levels including Team Leader)

Domainex has vacancies for talented laboratory-based analytical/bioanalytical chemists who are qualified to PhD or with BSc/MSc level in chemistry, life sciences or biochemistry with post-graduate analytical industry experience to support analysis and purification of synthetic molecules and bioanalysis from in vitro ADME studies.   The successful candidate will be required to demonstrate a thorough knowledge of analytical method and assay development, have hands-on experience of mass spectrometry and handling of microtitre plate-based samples.

The level of appointment will be commensurate with experience.  In addition to proven analytical skills, Domainex is particularly interested in hearing from applicants with experience in mammalian cell culture and protein analysis.  For consideration as a Team Leader, candidates must also have proven project management experience and prior supervisory/line management experience and perspectives on process enhancement. 

Main Roles and Responsibilities

  • Analytical assay development and delivery of results where your conclusions will guide projects
  • Contribute to the selection of bioanalytical assays to further clients mechanistic understanding for their projects
  • Support routine laboratory operation and maintenance
  • Prepare and present oral and written reports on research activities to internal and external audiences
  • Actively pursue own personal development
  • Line management opportunities
  • Maintain appropriate awareness of safety procedures, attend required safety training and adhere to laboratory safety rules as defined by the host department
  • Ensure that all duties are performed in accordance with organisational standards, policies and procedures
  • For team leader role: Report directly on your team’s performance to external clients and to the Domainex chemistry management team

If you would like to apply for one of these positions, please send your CV and a covering letter, quoting reference ABA0221 to recruitment2021@domainex.co.uk.

Closing Date: 15/08/2022, Please Note: These job postings will be closed as soon as sufficient applicants have been received.


Med Chem Associate Director and Group leader

Applications are invited from talented and experienced medicinal chemists with prior experience of line management for the role of Medicinal Chemistry Associate Director and Group leader.  You will hold a Ph.D. or a B.Sc/M.Sc. degree in organic or medicinal chemistry supported by a proven track record and delivery across hit identification, hit-to-lead and lead optimisation projects in large pharma or the biotech sector.  You will have an extensive knowledge of synthetic and medicinal chemistry and a thorough understanding of DMPK, toxicology and biology concepts in order to make key decisions for drug design. The role will involve significant interaction with external customers and will require excellent communication, good inter-personal skills and the ability to clearly summarise and present scientific results and ideas.

As this is a leadership position, previous experience of management of teams or groups is essential along with demonstrable experience of working with cross-discipline teams to successfully drive drug discovery projects.

Main Roles and Responsibilities

  • Line-manage medicinal chemistry team leaders and medicinal chemists of varying experience levels
  • Working with several clients to agree and implement project strategy and responsibility for the day-to-day reporting and communication of project progress to the clients
  • Providing leadership to multi-disciplinary project teams provision of insight to the future chemistry direction for the project
  • Provision of chemistry expertise to the business development team to assist in securing new business for Domainex
  • Play an active role as a member of the chemistry leadership team, using your knowledge to contribute to growing the department and influencing R&D strategy

If you would like to apply for this position, please send your CV and a covering letter, quoting Reference: GL0221 to recruitment2021@domainex.co.uk

Closing Date: 15/08/2022, Please Note: This job post will be closed as soon as sufficient applicants have been received.


Synthetic and Medicinal Chemist (all levels including team leaders)

Looking for the chance to use your scientific knowledge, to work alongside experienced researchers and contribute to the discovery of new treatments for patients? 

Domainex currently has opportunities for talented synthetic and medicinal chemistry laboratory-based scientists at all levels of experience including team leaders (project leaders) to join our research team. We’re an expanding contract research organisation (CRO) providing fully integrated, drug discovery services to the scientific community.  Our multi-disciplinary team works in a highly collaborative manner with our clients - bringing together talent, creativity and expertise to convert ideas and discoveries into new healthcare solutions.  Each client project brings new scientific challenges and our scientists must be versatile, and responsive to the evolving needs as each project progresses.

You may be involved in a range of synthetic projects and in Hit Identification, Hit-to-Lead, or Lead Optimisation programmes.

The successful candidates will have:

  • a Ph.D. in organic or medicinal chemistry, or a B.Sc/M.Sc. degree in chemistry and may also have additional experience in industry
  • a passion for synthetic chemistry and be able propose and execute synthetic routes efficiently
  • problem-solving ability from combining personal knowledge of synthetic methods and techniques, with the desire to seek-out and apply novel and innovative solutions from the wider literature
  • good communication skills; able to summarise and present scientific results and ideas to colleagues
  • excellent inter-personal skills
  • proven ability to work in a team, be proactive, and strive to deliver high quality

An ideal candidate will also have experience in some of the following areas:

  • experience in industry, with a proven track record
  • knowledge of DMPK, toxicology and biology concepts in order to make key decisions for drug design

Domainex is an award-winning company located in Cambridge, one of the UK’s leading hubs for bioscientific research and innovation, and offers a stimulating and rewarding research environment.

We currently have permanent opportunities available.  

If you would like to apply for one of these positions, please send your CV and a covering letter, quoting reference MSC1021 to recruitment2021@domainex.co.uk.

Please note: We are not accepting any enquiries or candidate profiles from recruitment organisations.

Closing Date15/08/2022


Analytical Chemists

Looking for the chance to use your scientific knowledge, to work alongside experienced researchers and contribute to the discovery of new treatments for patients? 

Domainex currently has opportunities for a talented analytical scientist to join our research team. We’re an expanding contract research organisation (CRO) providing fully integrated drug discovery services to the scientific community.  Our multi-disciplinary team works in a highly collaborative manner with our clients - bringing talent, creativity and expertise that converts ideas and discoveries into new healthcare solutions.  Each project brings new scientific challenges, and our scientists must be versatile and responsive to the evolving needs as each project progresses.

As an analytical scientist, you will be responsible for working with an established internal team to solve problems and deliver results for client projects.  A key element for this role this to support the growing chemistry department of currently 40 synthetic and medicinal chemists to maintain and repair Waters mass spectrometers, mass directed preparative instruments and to assist with challenging purification and chiral analysis/separation. Experience in this area is ideal, however, training will be given for candidates that have been identified with the appropriate technical skills to maintain and repair equipment.

In addition you will be part of an expanding analytical/bioanalytical team and will work at the interface between chemistry and biology, analysing samples prepared from a variety of biological matrices.  You will contribute to several different projects, across the whole drug discovery spectrum from Hit Identification to Lead Optimisation.  

The successful analytical/bioanalytical candidate will have:

  • M.Sc/ B.Sc/ degree in chemistry, natural sciences, or biochemistry.
  • Technically astute with problem-solving ability
  • Excellent inter-personal skills and proven ability to work in a team
  • Good communication skills; able to summarise and present scientific results and ideas to colleagues and external clients or collaborators as required
  • a proactive attitude, and strives to deliver high quality science

An ideal candidate will also have experience in some of the following areas:

  • Scientific instrument maintenance
  • LCMS, UPLC and MS/MS
  • HPLC,
  • NMR analysis

Domainex is an award-winning company located in Cambridge, one of the UK’s leading hubs for bioscientific research and innovation, and offers a stimulating and rewarding research environment.

If you would like to apply for one of these positions, please send your CV and a covering letter, quoting reference AC1121 to recruitment2021@domainex.co.uk.

Please note: We are not accepting any enquiries or candidate profiles from recruitment organisations.

Closing Date15/08/2022


Protein Sciences – Membrane Proteins (e.g. GPCRs, ion channels) - Senior Scientist - (Job Ref MPS0622)

Domainex has an exciting opportunity for a PhD level scientist (or BSc/MSc) with relevant experience in membrane protein expression, such as GPCRs or ion channels, to join our Protein Science Team in a lab-based role.  The level of appointment will be commensurate with experience.  You will be part of the Protein Science Team, which offers our clients a comprehensive range of services including: molecular biology; protein production for biochemical and biophysical assays, and for structural biology, including structural analysis of protein-ligand structures by X-ray crystallography.  We work closely with our colleagues in assay biology and medicinal chemistry. 

You will be able to work independently in membrane protein expression for protein or membrane preparations used in biochemical and biophysical analysis, including project planning, construct design, cloning, stable cell line generation, mammalian expression using transient expression, inducible vectors, BacMam system up to 10L scale. 

Experience with structural analysis of membrane proteins by CryoEM or X-ray crystallography is an advantage. Experience with SMALPS, amphipols or nanodiscs will be beneficial.  

Due to the diverse nature of the projects the team supports, you must be equally comfortable to work independently and as part of a team and able to handle working on multiple projects whilst maintaining high quality throughout. If you are a creative thinker, able to identify solutions to solve challenging problems to help progress client projects looking for the next career step we look forward to hearing from you. You will be fluent in English and be able to present complex science and data in a succinct and understandable manner.  

Main Roles and Responsibilities 

  • Plan and implement experimental protein production projects for membrane proteins such as GPCRs or ion channels, solving problems that arise 

  • Undertake protein production studies, including choice of expression system, construct design, cloning, stable cell line generation, mammalian expression using transient expression, inducible vectors, BacMam system up to 10L scale 

  • Support routine laboratory operation and maintenance 

  • Prepare and present oral and written reports on research activities to internal and external audiences 

  • Actively pursue own personal development 

  • Maintain appropriate awareness of safety procedures, attend required safety training and adhere to laboratory safety rules as defined by the host department 

  • Ensure that all duties are performed in accordance with organisational standards, policies and procedures 

To apply, please sending your CV, quoting reference MPS0622 to recruitment2021@domainex.co.uk

Closing date for applications: 15 August 2022 

This job post will be closed as soon as sufficient applicants have been received


Commercial Operations Scientist (proposals writer) – Part-Time or Full-Time

Domainex has a permanent vacancy for a highly organised individual ideally with a degree in a biology or chemistry discipline and prior experience of preparing technical documents in the drug discovery arena.

The successful applicant will have excellent communication skills and attention to detail.  The ability to communicate confidently with colleagues of varying levels of seniority and external customers will be a key requirement.  The successful candidate must have the ability to produce scientific workplans clearly in written form and have strong time management skills.  The ability to multi-task and have excellent IT skills are a pre-requisite. A thorough knowledge of the drug discovery process is required.  Previous experience of working in a CRO, whilst preferred, is not essential.

A willingness to work from our sites near Cambridge but also from home from time to time will be required.

Main Roles and Responsibilities

  • Liaising directly with colleagues in scientific operations to collate relevant information and knowledge 
  • Preparing scientific proposals and contracts based on discussions with potential customers
  • Working with colleagues in the business development team to ensure they have the information required in a timely manner

If you would like to apply for this position, please send your CV and a covering letter, quoting Reference: COS0222 to recruitment2021@domainex.co.uk

Closing Date: 15/08/2022, Please Note: This job post will be closed as soon as sufficient applicants have been received.


Marketing Manager – Part-Time or Full-Time

Domainex has a permanent vacancy for a creative and enthusiastic marketing manager with a degree in a biology or chemistry discipline. Ideally applicants will have prior relevant marketing experience obtained within a life science organisation, but this is not essential. 

The successful applicant will have the ability to communicate confidently with colleagues of varying levels of seniority and gather key information.  The ability to multi-task and have excellent IT skills are a pre-requisite. A good understanding of the drug discovery process is also essential. 

A willingness to work both from our sites near Cambridge but also from home from time to time will be required.

Main Roles and Responsibilities

Working closely with the Director of Commercial Operations and Domainex’s external marketing agency, you will:

  • Devise and deliver integrated marketing campaigns including new service launches and measure their impact
  • Regularly review and update Domainex’s website to ensure that it covers all of Domainex’s service offerings, that SEO is optimal and the content is engaging and clear
  • Issue press releases and utilise other communication platforms, especially social media to drive market engagement with prospects and customers
  • Gather external market intelligence and report on market developments to senior management
  • Oversee Domainex’s engagement with industry press and trade bodies so that the profile of the organisation is enhanced, culminating in the company securing further industry awards nominations
  • Seek to publicise marketing to internal colleagues and to gain their buy-in to initiatives that you devise
  • Organise events/conferences and ensure that such events are publicised and ROI is measured

If you would like to apply for this position, please send your CV and a covering letter, quoting Reference: MM0222 to recruitment2021@domainex.co.uk

Closing Date: 15/08/2022, Please Note: This job post will be closed as soon as sufficient applicants have been received


Head of Computational Chemistry

Applications are invited from talented and experienced computational chemists to establish and lead Domainex’s computational chemistry department.

The candidate will be a leader in the computational field providing strategic direction to drug discovery projects. The remit of the role will be to expand the computational group, however, in the short term the role will require a degree of ‘hands-on’ relevant experience. Previous experience of management of teams is desirable.

Main Roles and Responsibilities

  • Work within multi-disciplinary project teams and provide insight into the future drug discovery project direction and work closely with medicinal chemists and biologist to solve key project challenges.
  • Working with several clients to agree and implement project strategy, with responsibility for the day-to-day reporting and communication of project progress to the clients.
  • Manage the relationship with existing computational consultants and ensure project delivery.
  • Build a computational chemistry team for the future, ensuring scientific excellence by mentoring and line-managing computational scientists with varying experience levels.
  • Ensure delivery of client projects and provision of expert computational chemistry support to the medicinal chemistry team (currently 40 chemists)
  • Work closely with protein and structural biology groups to assist with protein structure determination.
  • Liaise with the biology team to assess druggability of protein targets to facilitate target selection.
  • Develop innovative solutions and workflows for the computational and medicinal chemistry teams.
  • Implementation of machine learning and AI workflows into the computational and drug design process.
  • Support the business development team by providing technical input and securing new business for Domainex.
  • Play an active role as a member of the chemistry leadership team, using your knowledge to contribute to growing the department and influencing R&D and company strategy.

You will hold a PhD or a BSc/MSc degree in computational chemistry or natural sciences, supported by a proven track record and delivery of projects to assist in the drug discovery projects across hit identification, hit-to-lead and lead optimisation projects in large pharma, biotech or CRO sectors.  You will have an extensive knowledge of computational chemistry. A thorough understanding of drug discovery and biology concepts would be advantageous in order to make key decisions for multidisciplinary drug discovery project teams. The role will involve significant interaction with external customers and the successful candidate will have excellent communication and inter-personal skills along with the ability to clearly summarise and present scientific results and ideas.

If you would like to apply for this position, please send your CV and a covering letter, quoting reference HCC0322 to recruitment2021@domainex.co.uk.

Closing Date: 15/08/2022, Please Note: This job post will be closed as soon as sufficient applicants have been received.


Principal Scientist Biophysics

Domainex is a fast-growing, privately-owned drug discovery service company, with a strong reputation for innovation. We support academic, biotechnology, patient foundation and pharmaceutical life-science organisations globally to progress their drug discovery programmes towards pre-clinical development. We are an ambitious organisation offering best-in-class services to our clients. We value our members of staff and foster an environment of continuous development and learning. 

We have a vacancy for a Principal Scientist in biophysics. This is an outstanding opportunity for talented and passionate biophysicist to have an influential role in drug discovery projects at a well-respected integrated medicines research CRO in Cambridge, UK.

Based within our Biology Department as a lab-based scientist within the Biophysics group, you will join a rapidly growing, talented team. The Biology Department has leading capabilities in biophysics, enzymology, crystallography, and cellular pharmacology and emerging expertise with cryo-EM. The Biophysics team has expertise in molecular biophysical methods, including SPR/GCI, MST, ITC and (nano)DSF. We apply biophysics for different phases of early drug discovery from hit ID through to candidate selection for a variety of different modalities: small-molecules, fragments, targeted protein degraders (ternary complex formation), RNA/DNA binders, antibodies and aptamers.

You will be working in a fast-paced environment as part of an inter-disciplinary team to generate and interpret data, determine next steps to drive projects forwards and contribute to proposal writing. You will have good problem-solving skills and able to regularly present data to key stakeholders internally and to clients through oral presentations and written reports.

Main roles and responsibilities

Working collaboratively on drug discovery projects as part of an inter-disciplinary team, you will be a lab-based scientist and develop innovative approaches to generate high-quality data for clients.

  • Develop bespoke biophysical assays using a range of techniques

  • Provide quantitative biophysical data on protein-ligand binding including affinity, kinetic or stoichiometric data to inform chemistry design and mechanistic understanding

  • Library screening (fragments, virtual) and SAR using a range of assays

  • Provide high quality data and insights on the molecular mechanism of compounds

  • Manage client projects

  • Train and mentor junior staff

  • Identify and drive improvements and innovations in capabilities.

  • Achieve personal scientific visibility through project contributions and client presentations, and external scientific visibility through conference presentations

  • Actively pursue own personal development

  • Maintain appropriate awareness of safety procedures, attend required safety training and adhere to laboratory safety rules as defined by the host department

  • Ensure that all duties are performed in accordance with organisational standards, policies and procedures

 

Essential Requirements

  • Formal training and proven expertise in molecular biophysics for medicines research with relevant industry experience

  • Deep understanding in a broad range of biophysical screening technologies

  • Extensive experience in biophysical characterisation of molecular interactions and mechanistic insights, using methods such as SPR, MST, ITC, DSF and fluorescence-based methods

  • A proven track record of scientific excellence

  • Demonstrate considerable experience in small-molecule drug discovery in the pharmaceutical or biotechnology industry

  • Experience in project leadership

Desirable

  • Line management experience

  • Experience in biochemical assays (e.g. HTRF, Luminescence, fluorescence polarisation) would be an advantage

*** We will be reviewing applications and shortlisting on a rolling basis - as such we reserve the right to withdraw this vacancy ahead of the stated closing date ***

To apply, please sending your CV, quoting reference PSB0822 to recruitment2022@domainex.co.uk

Closing date: 11/09/2022


Established in 2001, Domainex is a privately-owned, rapidly growing drug discovery services company with expertise spanning disease target expression, hit discovery, hit-to-lead identification and lead optimisation.

We have established an excellent reputation for providing high-quality and innovative drug discovery services and have an established track record of delivering preclinical drug candidates for our partners. Our clients include leading universities, biotechnology and pharmaceutical companies in the UK and overseas.

As a fast-growing technology company, Domainex offers a stimulating environment in which to work. Scientists are encouraged to be innovators, work collaboratively and above all to deliver high quality data and results to our customers.

For all roles, the successful candidate will have good attention to detail and high scientific standards and be able to demonstrate an enthusiasm for their chosen discipline and the broader field of drug discovery.  As an organisation, Domainex prides itself on providing innovative solutions to challenging problems, requiring a curiosity and desire to seek-out and apply novel and innovative solutions from the wider literature to progress Domainex’s customer projects and enhance our internal capabilities.  All roles will require regular interaction with new and existing customers requiring candidates to have well developed communication and inter-personal skills.  Domainex will provide opportunity and support to develop both scientific and personal skills further, as well as exposure to the project management skills and business acumen required to maintain a successful and growing CRO organisation. 

For all posts, we are legally obliged to confirm that the appointee is eligible to work in the UK before they start working for us. When applying for jobs it is important that you are aware of your eligibility status as government restrictions apply to the employment of migrant workers.  If invited to interview, you will be required to provide proof of your eligibility to work in the UK on your arrival.

For all positions please email your CV and a covering letter to recruitment2021@domainex.co.uk quoting the Job Reference number.

Due to the anticipated high number of applicants, we can only reply to candidates with the most relevant skills and experience. If you have not heard back from us within one month of submitting your application, please assume that you have been unsuccessful on this occasion.

Domainex is not accepting unsolicited assistance from search firms for any employment opportunities. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Domainex via email, the Internet or in any form and/or method without a valid written search agreement in place for any position will be deemed the sole property of Domainex. No fee will be paid in the event the candidate is hired by Domainex as a result of the referral or through other means.