Lead Discovery

Driving discovery, delivering leads

Generating better quality leads results in the accelerated discovery of better drug candidates.

Our expert scientific team works collaboratively with you through Hit ID and Hit-to-Lead, helping you to navigate even the most complex ‘Lead Discovery’ programmes and deliver high-quality leads and accelerate optimisation.

Hit Identification

Identify good quality hits that exhibit many of the characteristics of a final drug including efficient target binding, favourable molecular and physical properties and amenability to synthetic optimisation.

Our experts will work closely with you to recommend the best hit identification technique for your project. We combine extensive experience in drug discovery with state-of-the-art technologies to deliver the most efficient hit ID programmes that will help you to gain an early edge over your competitors.

Hit-to-Lead

Efficiently refine potential hits into the most promising leads to accelerate successful drug discovery.

Our team will employ a range of strategies to establish the potential of each of your hits as quickly as possible to focus subsequent lead optimisation work on the most promising chemical series. 

Lead Optimisation

Once we have established a strong lead compound or series, our multi-disciplinary team will move it seamlessly into lead optimisation.

We treat every project with the same commitment and determination as if it were our own, ensuring seamless progression and faster decisions for our clients. 

What our customers say about working with us

Their expertise in medicinal chemistry has enabled us not only to explore novel technology but also to accelerate drug discovery process. Domainex management team provides professional, strong work ethic as well as transparent communication.

Dr. Joon Seok Park
Chief of Drug Discovery Center, Daewoong Pharmaceutical Co., Ltd.

In a relatively short time period we achieved what would have taken at least twice as long with other companies.

Paul Lehner FmedSci FRS
Professor of Immunology and Medicine, University of Cambridge

We have been impressed by their ability to generate important data in various complex assays and to provide important insights and analysis.

Dr Paul Little
CEO, Vesper Bio ApS

Our project team at Domainex impressed us with their scientific rigour, excellent communication, and collaborative approach to problem-solving.

Dr Chris Tame & Dr Adam Yip
CEO, Project Lead, TernaryTx