Enrich your medicines pipeline

The research partner that creates innovative solutions, builds dynamic relationships and enriches your medicines pipeline across a range of human diseases

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Domainex provides a complete range of preclinical drug discovery services tailored to meet all your research needs.

Case Studies

MAP4K4: Kinase inhibitors for cardioprotection following heart attacks

Domainex designed novel, potent, highly selective, small-molecule inhibitors of MAP4K4, with potential cardioprotective drug properties. View more

Tankyrase: Inhibitors for the treatment of solid tumours

Domainex employed its LeadBuilder virtual screening technology to identify tankyrase inhibitors from which pre-clinical development candidates emerged. View more

Der p 1: Protease Inhibitors for the treatment of asthma

Domainex collaborated with St George’s University London & the University of Manchester on a programme of drug discovery which led to the successfully nomination of a candidate drug. View more

TBK1/IKKε: Kinase inhibitors for the treatment of interferonopathies

Domainex identified a drug candidate DMXD-011, a first-in-class small-molecule orally bioavailable inhibitor of TBK1/IKKε View more

FLIPP-FADD: PPI inhibitors for the treatment of solid tumours

Domainex and Queen's University Belfast have discovered the world’s first inhibitors of FLIP-FADD and produced viable leads for drug candidate selection View more

Ras: PPI inhibitors for the treatment of cancer

Domainex used its extensive experience of fragment- & structure-based drug design to develop a lead molecule with strong binding to RAS, an oncology target. View more

G9a: Lysine Methyltransferase Inhibitors for the Treatment of Cancer

Starting from a LeadBuilder screen we identified novel potent inhibitors of G9a, which have potential to be developed as treatments for a range of solid tumours. View more

G9a: A FBDD programme to identify lysine methyltransferase inhibitors for the treatment of cancer

Domainex identified several highly efficient fragment hits and after one round of elaboration a 10-fold increase in affinity was achieved. View more

News

APEIRON Biologics AG and Domainex Ltd announce the expansion of their partnership to progress targeted cancer immune therapy drug discovery

‘Are we seeing long-term shifts in the Scientific Research Landscape?’ webinar presented by Domainex as part of the OBN Digital Event Series

How can Domainex enrich your medicines pipeline?

Events

Nov 26 31st Symposium on Medicinal chemistry in Eastern England

Dec 10 Genesis 2020

Feb 25 OBN Awards

Tweets

Tweets by Domainex_UK

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