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Manufacturing Chemist | Expanding the medicinal chemist’s toolbox

Articles

FragmentBuilder: Integrated Fragment-Based Drug Design to Unlock your Disease Target

Brochure

Releasing the technical ‘shackles’ on GPCR drug discovery: opportunities enabled by detergent-free polymer lipid particle (PoLiPa) purification

Publication

OBN Digital Webinar - Are we seeing long-term shifts in the Scientific Research Landscape?

Presentation

Using TMRM to monitor changes in mitochondrial membrane potential

White Paper

Combinatorial Domain Hunting: Proprietary Technology for the Rapid Generation of Novel Protein Constructs

Brochure

PoLiPa: Innovative Polymer Lipid Particle (PoLiPa) Technology

Brochure

IKKe/TBK1: Case study of approaches to turning fragment hits into drug candidates

Presentation

LeadBuilder: Rapid Hit Identification via Virtual Screening

Brochure

Hit Identification - Understanding your target is key

Presentation

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

Publication

Fragment-Based Drug Design Using MicroScale Thermophoresis

Poster

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Domainex
  • About
    • Case Studies
    • Testimonials
    • Board members
    • Investors
    • Management team
    • Contact us
  • Services
    • Offerings
      • Protein Science
      • X-ray crystallography
      • Assay Development
      • Biophysics
      • Biochemistry
      • Synthetic Chemistry
      • Virtual screening
      • Screening
      • Computational Chemistry
      • Medicinal Chemistry
      • Cell Biology
      • ADME and Bioanalytical Sciences
      • Analytical Sciences
      • Grating-Coupled Interferometry
    • Research Phases
      • Hit Identification
      • Hit to Lead
      • Lead Optimisation
    • Therapeutic Areas
      • Oncology
      • Immuno-Oncology
      • Cardiovascular
      • Respiratory
      • Anti-infectives
      • Inflammatory diseases
    • Target Classes
      • Kinases
      • GPCRs
      • Proteases
      • Methyltransferases
      • Ion Channels
      • Protein-Protein Interactions
    • Approaches
      • CDH (Target Gene Fragmentation)
      • PoLiPa (Membrane Protein Solubilisation)
      • LeadBuilder
      • FragmentBuilder
      • Fragment Based Drug Discovery (FBDD)
      • Structure Based Drug Design (SBDD)
  • Library
    • Articles
    • Brochures
    • Posters
    • Presentations
    • Publications
    • White Papers
  • News & Events
  • Careers
COVID-19

+44 (0) 1223 743170 enquiries@domainex.co.uk

Offerings

  • Protein Science
  • X-Ray crystallography
  • Assay Development
  • Biophysics
  • Biochemistry
  • Synthetic Chemistry
  • Screening
  • Computational Chemistry
  • Medicinal Chemistry
  • Cell Biology
  • ADME and Bioanalytical Sciences
  • Analytical Sciences
  • Ligand binding assays by Surface Plasmon Resonance (SPR) and/or Grating-Coupled Interferometry (GCI)

Research Phases

  • Hit Identification
  • Hit to Lead
  • Lead Optimisation

Therapeutic Areas

  • Oncology
  • Immuno-Oncology
  • Cardiovascular
  • Respiratory Disease
  • Anti-infectives
  • Inflammatory diseases

Target Classes

  • Kinases
  • GPCRs
  • Proteases
  • Protein Methyltransferases
  • Ion Channels
  • Protein-Protein Interactions

Approaches

  • CDH (Target Gene Fragmentation)
  • Innovative Polymer Lipid Particle (PoLiPa) Technology
  • LeadBuilder – Virtual Screening
  • FragmentBuilder
  • Structure Based Drug Design (SBDD)

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