The use of Nanodiscs and spectral shift to tackle transmembrane targets

Jim Reid, Senior Principal Scientist - Protein Science at Domainex, presents "The use of Nanodiscs and spectral shift to tackle transmembrane targets: An A2a case study". Domainex described how careful construct engineering, optimised solubilisation strategies, and the use of nanodisc systems can yield stable membrane proteins suitable for direct binding assays, fragment screening, and antibody discovery.