Test and Analyse
The assay biology team at Domainex work with our medicinal chemists to devise the optimum screening cascade for your project, and can put in place the requisite assays within our laboratories along with our specialist partner organisations in pharmacokinetics and safety pharmacology to see your project through the entire drug discovery process. We minimise the time taken for each ‘design-make-test-analyse’ cycle, and when our clients elect to have all this work done by Domainex, we aim to complete each of these cycles within 10-15 working days. That means that within three months, for example, we will have completed at least 5-9 iterations. At that point, as well as aiming to have significantly improved the medicinal properties compared to the initial hit, we will have built you a wealth of information and knowledge about the lead series that can be added to your project as it moves into the lead optimisation stage.
Our Tankyrase, G9a and IKK-epsilon case studies show three examples of hit-to-lead programmes starting from fragment hits, and the Neuropilin-1 study demonstrates a literature-to-lead project that started with a peptide ligand.