Recent advances in biophysical and structural techniques mean that it is now possible to use several label-free approaches to gain crucial insights into ligand-target engagement by understanding the structural basis of drug binding, as well as measuring affinities (dissociation constants), kinetics (kon and koff) and energetics (enthalpic and entropic contributions to drug binding). Domainex is one of the leading experts in generation and interpretation of this data, and we use this knowledge on a routine basis to support both the Hit Identification and Lead Characterisation phases of your drug research projects.