Recruitment

Recruitment at Domainex – drug discovery CRO in Cambridge

 

Domainex is a fast-growing, privately-owned drug discovery service company, with a strong reputation for innovation. We support academic, biotechnology, patient foundation and pharmaceutical life-science organisations globally to progress their drug discovery programmes towards pre-clinical development. We are an ambitious organisation offering best-in-class services to our sponsors. We are based at a state-of-the-art 20,000 square-foot facility at the Chesterford Research Park near Cambridge, UK and are a co-located, multi-disciplinary team of chemists and biologists with a friendly, collaborative, can-do approach to our work.

 

Complementing an ambitious growth strategy, we are actively investing in our people and technologies, and looking to strengthen our teams.  If you would like to join us, and have the skills and experience we are looking for, we would love to hear from you.    ​


 


Computational Chemist

Are you looking for the chance to use your scientific knowledge, to work alongside experienced researchers, and contribute to the discovery of new treatments for patients?  Domainex currently has an opportunity for a talented computational chemist to join its research team.  Using our comprehensive suite of software tools our CADD team deliver tailored solutions to the problems posed by our portfolio of client projects.

Domainex has one position available for an experienced computational chemist.   This is an exciting opportunity with the remit to influence and further develop our computational chemistry team and capabilities.    As an experienced computational chemist, you will be involved in multiple projects drawn from a range of therapeutic areas and at different stages from initial hit identification to lead optimisation.  You will also play a leading role in the ongoing development of platform technologies within the company, such as our fragment-based screening capability.

Excellent organisation and planning skills are essential, to enable working across multiple projects.  You will be responsible for working with the client to agree a project strategy. Communication of results to clients and internal project teams will be required, and a successful candidate will also have the opportunity to take part in business development activities.  You will have the opportunity to line-manage a further computational chemist.

The Successful candidate will have:

  • A Ph.D. in computational chemistry, or a B.Sc/M.Sc. degree in a life science; and in-depth experience of small-molecule and protein modelling.
  • Structure-based and ligand-based drug design experience of greater than 5 years, with a proven track record in project delivery
  • Experience applying a wide range of computational tools and techniques including virtual screening, structure-activity relationships, and chemoinformatics.
  • Knowledge of drug discovery processes; appreciation of key concepts from collaborating disciplines such as medicinal chemistry and biophysics
  • Problem-solving ability from combining personal knowledge of computational techniques with the a desire to seek-out and apply novel and innovative solutions from the wider literature
  • Proactive attitude, and strives to deliver high-quality results
  • Excellent inter-personal skills and proven ability to work in a team; good communication skills, able to summarise and present scientific results and ideas to colleagues and external clients/collaborators
  • Able to provide leadership to a team of talented scientists and work well within multi-disciplinary projects
  • A business-mindset in order to identify new opportunities and contribute to proposal writing.

If you would like to apply for this permanent position, please send your CV and a covering letter, quoting ECC0620 to recruitment2020@domainex.co.uk

Closing Date: 31st July 2020


Team Leader - Medicinal Chemistry

Looking for the chance to use your scientific knowledge, to work alongside experienced researchers and contribute to the discovery of new treatments for patients? 

Domainex currently has opportunities for talented medicinal chemistry team leaders (project leaders) to join our research team.   Each client project brings new scientific challenges and our scientists must be versatile, and responsive to the evolving needs as each project progresses.

As a medicinal chemistry project team leader, you will be responsible for working with the client to agree project strategy and reporting results, and providing leadership to a multi-disciplinary project team. You will line-manage medicinal chemists at the associate, scientist and senior scientist levels. A successful applicant will report directly to an experienced group leader and be required to contribute to the expansion and evolution of our growing department.

You may be responsible for one or more projects, depending on their size, and be involved in projects from Hit Identification, Hit-to-Lead, or Lead Optimisation projects.

Successful candidates will have:

  • a Ph.D. in organic or medicinal chemistry, or a B.Sc/M.Sc. degree in chemistry.
  • experience in industry of greater than 5 years, with a proven track record in project delivery
  • knowledge of DMPK, toxicology and biology concepts in order to make key decisions for drug design
  • a passion for synthetic and medicinal chemistry
  • problem-solving ability from combining personal knowledge of synthetic methods and techniques, with the desire to seek-out and apply novel and innovative solutions from the wider literature
  • able to provide leadership for a team of talented chemists and within multi-disciplinary projects
  • good communication skills; able to summarise and present scientific results and ideas to colleagues and external clients/collaborators
  • excellent inter-personal skills
  • proven ability to work in a team, be proactive, and strive to deliver high quality
  • be business-minded in order to identify new opportunities and contribute to proposal writing.

We currently have permanent opportunities available.  

If you would like to apply for one of these positions, please send your CV and a covering letter, quoting reference TL0620  to recruitment2020@domainex.co.uk.

Closing Date: 31 July 2020


Protein Scientist/Structural Biologist

Do you feel passionate about biomedical research? Can you purify high-quality recombinant proteins? Can you solve protein-ligand structures? Does the challenge of solving difficult problems involved in the invention of new medicines excite you? If so, we are looking for you!

Domainex has a permanent vacancy in our Protein Science Team, which offers our clients a comprehensive range of services including: molecular biology; protein production for biochemical and biophysical assays, and for structural biology; and structural analysis of proteins by X-ray crystallography. Our unique, patented, Combinatorial Domain Hunting technology allows us to make and work with proteins that are otherwise refractory to recombinant expression.

Successful candidates

  • Will have expertise in molecular biology; recombinant protein expression and purification in E. coli, insect, or mammalian cells
  • Will have experience of using AKTA chromatography equipment (or similar) for protein purification to X-ray crystallography standard
  • Ideally are able to solve X-ray crystal structures independently and have a good working knowledge of the current software packages employed in protein crystallography (esp. XDS, CCP4, coot); if you have experience of solving structures of protein-ligand complexes over a range of target classes in a drug discovery environment that would be even better!
  • Experience in the use of biophysical techniques for characterisation of proteins and their binding interactions would also be a significant plus.

This role requires you to plan and implement experimental programmes, to solve any problems that arise, and to work effectively within project teams to deliver high-quality results to our clients. Laboratory work is a major element of this varied and challenging role.  You will need to diligently interpret your data and report your results, and you must be able to make recommendations for further studies. You will also be discussing your results directly with our clients, and agreeing with them the next steps, so good communications skills are a must.

Job requirements

  • PhD with track-record of relevant and proven experience, i.e. publications and PDB depositions where applicable.
  • Independence and team working; flexibility to take on different projects; ability to make a meaningful impact on clients.
  • Ability to work on your own initiative, and to consistently deliver high quality results.
  • Creative thinking coupled to delivery of novel outcomes that leads to opportunities for inventorship or publications (papers/research articles).

To apply for this role, please send your CV and a covering letter, quoting reference PSSB0520, to recruitment2020@domainex.co.uk.


Bio-analytical/Analytical Scientist

Looking for the chance to use your scientific knowledge, to work alongside experienced researchers and contribute to the discovery of new treatments for patients? 

Domainex currently has opportunities for a talented analytical/bioanalytical scientist to join our research team. We’re an expanding contract research organisation (CRO) providing fully integrated drug discovery services to the scientific community.  Our multi-disciplinary team works in a highly collaborative manner with our clients - bringing talent, creativity and expertise that converts ideas and discoveries into new healthcare solutions.  Each project brings new scientific challenges and our scientists must be versatile and responsive to the evolving needs as each project progresses.

As an analytical/bioanalytical scientist, you will be responsible for working with an established internal team to solve problems and deliver results for client projects.  You will work at the interface between chemistry and biology, analysing samples prepared from a variety of biological matrices.  You will contribute to several different projects, across the whole drug discovery spectrum from Hit Identification to Lead Optimisation.  

The successful applicant will work with an experienced analytical group leader and contribute to the expansion and evolution of our growing department.

The successful candidate will have:

  • Ph.D/ M.Sc/ B.Sc/ degree in chemistry, natural sciences, or biochemistry.
  • Industrial experience (ideally more than 2 years), with a proven track record in analytical assay development and delivery of results where your conclusions have guided projects
  • experience with mass spectrometry (LC-MS, LC-MSMS)
  • experience with plate-based assays
  • the ability to generate bespoke assays for client-based projects, with support from experienced colleagues as required
  • excellent attention to detail
  • possess good inter-personal skills and a proven ability to work in a team
  • good communication skills; able to summarise and present scientific results and ideas to colleagues and external clients or collaborators as required
  • a proactive attitude, and strives to deliver high quality science

The  candidate will ideally have experience in some of the following areas:

  • In vitro ADME and related assays e.g. hepatocyte stability, plasma-protein binding
  • Handling of mammalian cells
  • Bio-analysis

Domainex is an award-winning company located in Cambridge, one of the UK’s leading hubs for bioscientific research and innovation, and it offers a stimulating and rewarding research environment.

This is a permanent position.  

 

If you would like to apply for this job, please send your CV and a covering letter, quoting reference BAS0820 to recruitment2020@domainex.co.uk.

Closing Date: 30 September 2020

 


Protein Scientist

Would you like to make a major contribution to the discovery of new treatments for patients by using your scientific knowledge?   If so, you will want to know that Domainex has a full-time permanent job vacancy for a Protein Scientist with biochemistry and/or biophysics experience to join our growing team.

This role primarily involves:

  • Using cutting-edge research to advance our customers’ drug discovery programmes.
  • Responsibility for developing and performing biochemical and biophysical assays (e.g. thermal shift assays, kinetic or endpoint enzyme assays, fluorescence polarisation, microscale thermophoresis).
  • Data analysis and interpretation in order to produce reliable and precise reports that can be provided to clients.
  • Working in close collaboration with colleagues in medicinal chemistry and analytical chemistry to provide integrated drug discovery solutions.
  • Working efficiently and diligently to meet deadlines.
  • Very diverse and fast-changing workload, so you must enjoy working in a dynamic environment! 

We are looking for scientists who are qualified to PhD level in biological research, preferably molecular biology or biochemistry, or are BSc graduates with several years’ of relevant experience within the biomedical sector. Previous experience in developing and carrying-out assays against isolated proteins is desirable but not essential, and additional training will be provided to broaden your skill-set.  The successful candidate will be enthusiastic, a quick learner, have good problem-solving skills, and be able to work effectively in a team.  

To apply, please send your CV and a covering letter, quoting reference PS0220, to recruitment2020@domainex.co.uk

Please note: We are not accepting any enquiries or candidate profiles from recruitment organisations.

 


Established in 2001, Domainex is a privately-owned, rapidly growing drug discovery services company with expertise spanning disease target expression, hit discovery, hit-to-lead identification and lead optimisation.

We have established an excellent reputation for providing high-quality and innovative drug discovery services and have an established track record of delivering preclinical drug candidates for our partners. Our clients include leading universities, biotechnology and pharmaceutical companies in the UK and overseas.

As a fast-growing technology company, Domainex offers a stimulating environment in which to work. Scientists are encouraged to be innovators, work collaboratively and above all to deliver high quality data and results to our customers.

For all posts, we are legally obliged to confirm that the appointee is eligible to work in the UK before they start working for us. When applying for jobs it is important that you are aware of your eligibility status as government restrictions apply to the employment of migrant workers. If invited to interview, you will be required to provide proof of your eligibility to work in the UK on your arrival.

Due to the anticipated high number of applicants, we can only reply to candidates with the most relevant skills and experience. If you have not heard back from us within one month of submitting your application, please assume that you have been unsuccessful on this occasion.

Domainex is not accepting unsolicited assistance from search firms for any employment opportunities.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Domainex via email, the Internet or in any form and/or method without a valid written search agreement in place for any position will be deemed the sole property of Domainex.  No fee will be paid in the event the candidate is hired by Domainex as a result of the referral or through other means.