Recruitment

Recruitment at Domainex – drug discovery CRO in Cambridge

 

Domainex is seeking highly motivated and ambitious laboratory-based scientists with a passion for drug discovery research. We pride ourselves on our strong work ethic and our friendly, supportive environment where scientists are encouraged to develop skills and build their careers.

Complementing an ambitious growth strategy, we are actively investing in our people and technologies, and looking to strengthen our Bioassay and Chemistry teams.  If you would like to join us, and have the skills and experience we are looking for, we would love to hear from you.    


Protein Scientist/ Structural Biologist

Domainex has a full-time permanent vacancy in our Protein Science Team, which offers our clients a comprehensive range of services including molecular biology, protein production for assays and structural biology, and structural analysis of proteins by X-ray crystallography.  Our unique, patented, Combinatorial Domain Hunting technology allows us to make and work with proteins that are otherwise refractory to recombinant expression.

 

All applicants must have expertise in molecular biology; recombinant protein expression and purification in E. coli, insect or mammalian cells; and substantial experience of using AKTA chromatography equipment (or similar) for protein purification to X-ray crystallography standard. Candidates must also be able to solve X-ray crystal structures independently and have a good working knowledge of the current software packages employed in protein crystallography (esp. XDS, CCP4, coot).  Experience of protein-fragment crystallography, and biophysical techniques would be a significant plus.

 

This role requires the ability to plan and implement experimental programmes, to solve any problems that arise, and to work effectively within project teams to deliver high-quality results to our clients. Laboratory work is a major element of this varied and challenging role.  Essential attributes include diligent reporting of results, data interpretation, and an ability to make recommendations for further studies. It will also be necessary to communicate your results effectively to our clients.

 

Job requirements

PhD with track-record of relevant and proven experience, i.e. publications and PDB depositions.

Independence and team working; flexibility to take on different projects; ability to make a meaningful impact on clients.

Ability to work on your own initiative, and to consistently deliver high quality results.

Creative thinking coupled to delivery of novel outcomes that leads to opportunities for inventorship or publications (papers/research articles).

To apply for this role, please send your CV and a covering letter, quoting reference PS0219, to recruitment2019@domainex.co.uk.


Medicinal Chemists

Domainex currently has temporary positions available for motivated laboratory-based medicinal chemists.  

 

Our ideal candidates will have either a Ph.D. in organic or medicinal chemistry, or a B.Sc/M.Sc. degree in chemistry, and may also have additional drug discovery experience in an industrial setting. Successful candidates will have skills and experience in the following areas:

 

  • Organic synthesis: Able to plan and execute synthetic programmes, combining personal knowledge with literature searching to identify appropriate synthetic routes.  Work efficiently in the laboratory.
  • Team-work: Able to work closely with colleagues to plan and integrate their efforts to achieve the project objectives as efficiently and effectively as possible.
  • Communication:  Able to summarise and present scientific results to colleagues.

 

Domainex offers a stimulating environment in which to work. Staffed with scientists with varying disciplines in a non-hierarchical, matrix structure within a single location, our drug-hunting teams are encouraged to be innovators, work collaboratively and above all to serve the needs of its customers.

 

Closing date for applicants is 15th April 2019.  If you would like to apply for one of these positions, please send your CV and a covering letter, quoting reference CS0419, to recruitment2019@domainex.co.uk.

 


Assay Biologists

Domainex has full-time permanent job vacancies in Assay Biology. We offer our clients a comprehensive range of assay services including biochemical, biophysical and cell-based assay development, high-throughput screening, compound profiling (potency, selectivity, phenotype, and mechanism of action) and off-target ADME/safety assessment to support the generation of pre-clinical candidates.

These roles require the ability to plan and implement experimental programmes, to solve any problems that arise, and to work effectively within project teams to deliver high-quality data to our clients. Laboratory work is a major element of these varied and challenging roles, and most of our bioassays are run on automated instrumentation.  Other essential attributes include diligent reporting of results, data interpretation and an ability to make recommendations for further studies. It will also be necessary to communicate your results effectively to our clients.

All applicants should ideally have some prior experience of doing biochemical, biophysical and/or cellular assays in at least one of the following categories; enzyme kinetics, receptor binding studies, biophysical assays, cellular efficacy and/or mechanism of action studies. Candidates must have experience of working with microtitre plate-based assays, preferably in a drug discovery setting, will have developed assays for compound screening and potency determination in a variety of formats, and should be proficient in data processing and analysis. 

Job requirements

Associate Scientist

Minimum of BSc.

Independence; flexibility to take on different projects.

Able to make tangible contribution to projects worked on through timely delivery of high-quality results.

To apply for the Associate Scientist role, please sending your CV and a covering letter, quoting reference ABA0618, to recruitment2019@domainex.co.uk

Senior Scientist 

BSc or PhD with a number of years of relevant and proven drug discovery experience.

Independence and team working; able to direct the work of others and make meaningful impact on clients.

Ability to deliver high quality results consistently.

Ability to take the initiative.

Creative thinking coupled to delivery of novel outcomes that leads to opportunities for inventorship or publications (papers/research articles).

To apply for the Senior Scientist role, please sending your CV and a covering letter, quoting reference SBA0618, to recruitment2019@domainex.co.uk


Established in 2001, Domainex is a privately-owned, rapidly growing drug discovery services company with expertise spanning disease target expression, hit discovery, hit-to-lead identification and lead optimisation.

We have established an excellent reputation for providing high-quality and innovative drug discovery services and have an established track record of delivering preclinical drug candidates for our partners. Our clients include leading universities, biotechnology and pharmaceutical companies in the UK and overseas.

As a fast-growing technology company, Domainex offers a stimulating environment in which to work. Scientists are encouraged to be innovators, work collaboratively and above all to deliver high quality data and results to our customers.

For all posts, we are legally obliged to confirm that the appointee is eligible to work in the UK before they start working for us. When applying for jobs it is important that you are aware of your eligibility status as government restrictions apply to the employment of migrant workers. If invited to interview, you will be required to provide proof of your eligibility to work in the UK on your arrival.

Due to the anticipated high number of applicants, we can only reply to candidates with the most relevant skills and experience. If you have not heard back from us within one month of submitting your application, please assume that you have been unsuccessful on this occasion.

Domainex is not accepting unsolicited assistance from search firms for any employment opportunities.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Domainex via email, the Internet or in any form and/or method without a valid written search agreement in place for any position will be deemed the sole property of Domainex.  No fee will be paid in the event the candidate is hired by Domainex as a result of the referral or through other means.