Recruitment at Domainex – drug discovery CRO in Cambridge

Domainex is seeking highly motivated and ambitious laboratory-based scientists with a passion for drug discovery research. We pride ourselves on our strong work ethic and our friendly, supportive environment where scientists are encouraged to develop skills and build their careers.

Complementing an ambitious growth strategy, we are actively investing in our people and technologies, and looking to strengthen our Bioassay and Chemistry teams.  If you would like to join us, and have the skills and experience we are looking for, we would love to hear from you.    

Protein Scientist/ Structural Biologist

Domainex has a full-time permanent vacancy in our Protein Science Team, which offers our clients a comprehensive range of services including molecular biology, protein production for assays and structural biology, and structural analysis of proteins by X-ray crystallography.  Our unique, patented, Combinatorial Domain Hunting technology allows us to make and work with proteins that are otherwise refractory to recombinant expression.

All applicants must be able to solve X-ray crystal structures independently and have a good working knowledge of the current software packages employed in protein crystallography (esp. XDS, CCP4, coot). They should be able to demonstrate postdoctoral level experience of solving structures of protein-ligand complexes over a range of target classes in a drug discovery environment, experience in the use of biophysical techniques would be a significant plus. Candidates must also have expertise in molecular biology; recombinant protein expression and purification in E. coli, insect or mammalian cells; and substantial experience of using AKTA chromatography equipment (or similar) for protein purification to X-ray crystallography standard.

This role requires the ability to plan and implement experimental programmes, to solve any problems that arise, and to work effectively within project teams to deliver high-quality results to our clients. Laboratory work is a major element of this varied and challenging role.  Essential attributes include diligent reporting of results, data interpretation, and an ability to make recommendations for further studies. It will also be necessary to communicate your results effectively to our clients.


Job requirements:

PhD with track-record of relevant and proven experience, i.e. publications and PDB depositions.

Independence and team working; flexibility to take on different projects; ability to make a meaningful impact on clients.

Ability to work on your own initiative, and to consistently deliver high quality results.

Creative thinking coupled to delivery of novel outcomes that leads to opportunities for inventorship or publications (papers/research articles).


To apply for this role, please send your CV and a covering letter, quoting reference PS0519, to


Medicinal Chemists

Domainex doesn't currently have any vacancies for medicinal chemists. However, we are happy to receive speculative applications from talented scientists.

Please send your CV and a covering letter to


Assay Biologists

Domainex doesn't currently have any vacancies for assay biologists. However, we are happy to receive speculative applications from talented scientists.

Please send your CV and a covering letter to



Established in 2001, Domainex is a privately-owned, rapidly growing drug discovery services company with expertise spanning disease target expression, hit discovery, hit-to-lead identification and lead optimisation.

We have established an excellent reputation for providing high-quality and innovative drug discovery services and have an established track record of delivering preclinical drug candidates for our partners. Our clients include leading universities, biotechnology and pharmaceutical companies in the UK and overseas.

As a fast-growing technology company, Domainex offers a stimulating environment in which to work. Scientists are encouraged to be innovators, work collaboratively and above all to deliver high quality data and results to our customers.

For all posts, we are legally obliged to confirm that the appointee is eligible to work in the UK before they start working for us. When applying for jobs it is important that you are aware of your eligibility status as government restrictions apply to the employment of migrant workers. If invited to interview, you will be required to provide proof of your eligibility to work in the UK on your arrival.

Due to the anticipated high number of applicants, we can only reply to candidates with the most relevant skills and experience. If you have not heard back from us within one month of submitting your application, please assume that you have been unsuccessful on this occasion.

Domainex is not accepting unsolicited assistance from search firms for any employment opportunities.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Domainex via email, the Internet or in any form and/or method without a valid written search agreement in place for any position will be deemed the sole property of Domainex.  No fee will be paid in the event the candidate is hired by Domainex as a result of the referral or through other means.