Recruitment

Recruitment at Domainex – drug discovery CRO in Cambridge

Domainex is a fast-growing, privately-owned drug discovery service company, with a strong reputation for innovation. We support academic, biotechnology, patient foundation and pharmaceutical life-science organisations globally to progress their drug discovery programmes towards pre-clinical development. We are an ambitious organisation offering best-in-class services to our sponsors. We are based at a state-of-the-art 20,000 square-foot facility at the Chesterford Research Park near Cambridge, UK and are a co-located, multi-disciplinary team of chemists and biologists with a friendly, collaborative, can-do approach to our work.

 

Complementing an ambitious growth strategy, we are actively investing in our people and technologies, and looking to strengthen our teams.  If you would like to join us, and have the skills and experience we are looking for, we would love to hear from you.    ​


Head of Assay Biology

Do you feel passionate about biomedical research?  Are you qualified to PhD level in life sciences with several years of industrial experience in developing and implementing small-molecule screening assays in both biochemical and cellular formats? Does the challenge of solving difficult problems in assay development excite you? Do want to lead a bioassay group involved in the invention of new medicines?  If so, you might very well be the candidate we are looking for!

Domainex is a fast-growing, privately-owned drug research services company, with a strong reputation for innovation. We support biotechnology, pharmaceutical, patient foundation, and academic life-science organisations from around the globe in progressing their drug discovery programmes towards pre-clinical development. We are an ambitious organisation offering best-in-class services to our clients. We are based at a state-of-the-art 2,000m2 facility at the Chesterford Research Park near Cambridge, UK and our co-located, multi-disciplinary team of talented chemists and biologists has a friendly, collaborative, can-do approach, and they love their science!

We are now seeking a Head of Assay Biology to lead our group of bioassay scientists.  The job holder will line manage team leaders and scientists deployed in flexibly organised teams according to the needs of our client programmes.  In addition, they will also be responsible for leading one or more projects that could be multi-disciplinary in nature.  We are also looking for someone who can identify profitable opportunities for new products and services, and who can devise and implement the R&D required to develop these and demonstrate their utility to our customers.  The role also requires supporting our sales and marketing efforts to secure new business from existing and prospective clients and to launch new service offerings.

The successful candidate will have had several years of hands-on assay biology experience in an industrial small-molecule drug discovery setting; they will be experienced in assay development as well as routine screening to develop SAR using both biochemical and phenotypic cellular formats; and in characterising the in vitro pharmacology of prospective drug candidates.  They will be familiar with a wide range of bioassay instruments and with the laboratory automation used for plate formatting, although experience of using high-throughput robotics is not necessary, as Domainex does not conduct HTS campaigns in-house.  Crucially, the job holder also has to be able to discern and understand our clients’ detailed needs, and then conceive and write-up compelling science plans and research proposals that address these requirements.  We have specialist expertise in structure-based and fragment-based drug design, and our ideal candidate would have experience of these areas, and of using biophysical techniques for screening and compound characterisation.

Remuneration: The position offers a competitive salary with generous company pension scheme and life insurance benefit.

If you would like to apply for this position, please send your CV and a covering letter, quoting reference HAB0719 to recruitment2019@domainex.co.uk

Please note: We are not accepting any enquiries or candidate profiles from recruitment organisations.


Medicinal Chemists

Looking for the chance to use your scientific knowledge, to work alongside experienced researchers and contribute to the discovery of new treatments for patients?  Domainex currently has opportunities for talented laboratory-based synthetic and medicinal chemists to join our research team. We’re an expanding contract research organisation providing fully integrated, drug discovery services to the scientific community.  Our multi-disciplinary team works in a highly collaborative manner with our clients - bringing together talent, creativity and expertise to convert ideas and discoveries into new healthcare solutions.  Each client project brings new scientific challenges and our scientists must be versatile, and responsive to the evolving needs as each project progresses.

Successful candidates will have:

  • a Ph.D. in organic or medicinal chemistry, or a B.Sc/M.Sc. degree in chemistry and may also have additional experience in industry
  • a passion for synthetic chemistry and be able propose and execute synthetic routes efficiently
  • problem-solving ability from combining personal knowledge of synthetic methods and techniques, with the desire to seek-out and apply novel and innovative solutions from the wider literature
  • good communication skills; able to summarise and present scientific results and ideas to colleagues
  • proven ability to work in a team, be proactive, and strive to deliver high quality

Domainex is an award-winning company located in Cambridge, one of the UK’s leading hubs for bioscientific research and innovation, and offers a stimulating and rewarding research environment.

We currently have permanent and fixed-term opportunities available.  

Closing date: 31 October 2019

If you would like to apply for one of these positions, please send your CV and a covering letter, quoting reference CS1019 to recruitment2019@domainex.co.uk.

Please note: We are not accepting any enquiries or candidate profiles from recruitment organisations.


Associate Protein Scientist

Do you feel passionate about biomedical research? Does the challenge of solving problems that lead to the invention of new medicines excite you? If your degree or PhD has trained you in molecular biology and protein expression, then we are looking for you!

We have a permanent vacancy in our Protein Science Team, which offers our clients a comprehensive range of services including molecular biology, protein production for biochemical and biophysical assays and structural biology, and structural analysis of proteins by X-ray crystallography.  Our unique, patented, Combinatorial Domain Hunting technology allows us to make and work with proteins that are otherwise refractory to recombinant expression.

The applicants must be familiar with standard molecular biology techniques: i.e. PCR, bacterial transformation, purification of plasmid preps from bacterial cultures (minipreps), DNA and protein electrophoresis, and Western blotting; as well as recombinant protein expression and purification.  Experience of using AKTA chromatography equipment (or similar) for protein purification is desirable.  Our experienced team will provide any on the job training that may be required to complement your current knowledge and to enable you to deliver on the projects: for example using a range of different expression hosts, optimisation strategies for protein expression, purification techniques, and protein quality-control methods. You will be part of a multi-disciplinary environment and see how your work helps to accelerate drug discovery programmes with the aim of overcoming cancer and other diseases.

This role requires the ability to work effectively within project teams to deliver high-quality results to our clients. Laboratory work is the major element of this varied and challenging job, and essential attributes include diligent reporting of your results and an eagerness to learn.

Job requirements:

  • Qualified with a minimum of a good BSc, ideally a PhD, including some relevant experience of molecular biology and protein expression techniques.
  • Independence and team working; flexibility to take on different projects.
  • Ability to work on your own initiative, and to consistently deliver high quality results.
  • Creative thinking coupled to delivery of novel outcomes.

To apply for this role, please send your CV and a covering letter, quoting reference PS0919, to recruitment2019@domainex.co.uk.


Protein Scientist/ Structural Biologist

Domainex has a full-time permanent vacancy in our Protein Science Team, which offers our clients a comprehensive range of services including molecular biology, protein production for assays and structural biology, and structural analysis of proteins by X-ray crystallography.  Our unique, patented, Combinatorial Domain Hunting technology allows us to make and work with proteins that are otherwise refractory to recombinant expression.

All applicants must be able to solve X-ray crystal structures independently and have a good working knowledge of the current software packages employed in protein crystallography (esp. XDS, CCP4, coot). They should be able to demonstrate postdoctoral level experience of solving structures of protein-ligand complexes over a range of target classes in a drug discovery environment, experience in the use of biophysical techniques would be a significant plus. Candidates must also have expertise in molecular biology; recombinant protein expression and purification in E. coli, insect or mammalian cells; and substantial experience of using AKTA chromatography equipment (or similar) for protein purification to X-ray crystallography standard.

This role requires the ability to plan and implement experimental programmes, to solve any problems that arise, and to work effectively within project teams to deliver high-quality results to our clients. Laboratory work is a major element of this varied and challenging role.  Essential attributes include diligent reporting of results, data interpretation, and an ability to make recommendations for further studies. It will also be necessary to communicate your results effectively to our clients.

Job requirements:

  • PhD with track-record of relevant and proven experience, i.e. publications and PDB depositions.
  • Independence and team working; flexibility to take on different projects; ability to make a meaningful impact on clients.
  • Ability to work on your own initiative, and to consistently deliver high quality results.
  • Creative thinking coupled to delivery of novel outcomes that leads to opportunities for inventorship or publications (papers/research articles).

To apply for this role, please send your CV and a covering letter, quoting reference PS0519, to recruitment2019@domainex.co.uk.


Assay Biologist

Domainex has full-time permanent job vacancies in Assay Biology. The Company offers its clients a comprehensive range of assay services including biochemical, biophysical and cell-based assay development, high-throughput screening, compound profiling (potency, selectivity, phenotype, and mechanism of action) and off-target ADME/safety assessment to support the generation of pre-clinical candidates.

All applicants must have some prior experience of doing biochemical assays in at least one of the following categories; enzyme kinetics, mechanism of action studies, or using Mass Spectrometry for detection. Candidates must also have experience of working with microtitre plate-based assays, preferably in a drug discovery setting, should have developed assays for compound screening and potency determination in a variety of formats, and ideally will be proficient in data processing and analysis. 

These roles require the ability to plan and implement experimental programmes, to solve any problems that arise, and to work effectively within project teams to deliver high-quality data to our clients. Laboratory work is a major element of these varied and challenging roles, and most of our bioassays are run using automated instrumentation, but not HTS platforms.  Other essential attributes include diligent reporting of results, data interpretation and an ability to make recommendations for further studies. It will also be necessary to communicate your results effectively to our clients.

Job requirements

Associate Scientist

Minimum of BSc.

Independence; flexibility to take on different projects.

Able to make tangible contribution to projects worked on through timely delivery of high-quality results.

Scientist

BSc with several years of relevant post-graduate industrial experience, or PhD with some industrial experience.

Independence and team working; able to influence the work of others and make meaningful impact on client projects.

Ability to deliver high quality results consistently within timelines.

Creative thinking coupled to delivery of novel outcomes that leads to opportunities for inventorship or publications (papers/research articles).

Effective presentation skills.

Senior Scientist 

At least 2-3 years’ proven experience in enzyme kinetics

BSc or PhD with several years of relevant and proven drug discovery experience.

Independence and team working; able to direct the work of others and solve challenging problems that may arise during client project work.

Ability to deliver high quality results consistently within timelines.

Ability to take the initiative, anticipate problems and work around them.

Creative thinking coupled to delivery of novel outcomes that leads to opportunities for inventorship or publications (papers/research articles).

 

To apply, please sending your CV and a covering letter, quoting reference AB0719, to recruitment2019@domainex.co.uk

 


Established in 2001, Domainex is a privately-owned, rapidly growing drug discovery services company with expertise spanning disease target expression, hit discovery, hit-to-lead identification and lead optimisation.

We have established an excellent reputation for providing high-quality and innovative drug discovery services and have an established track record of delivering preclinical drug candidates for our partners. Our clients include leading universities, biotechnology and pharmaceutical companies in the UK and overseas.

As a fast-growing technology company, Domainex offers a stimulating environment in which to work. Scientists are encouraged to be innovators, work collaboratively and above all to deliver high quality data and results to our customers.

For all posts, we are legally obliged to confirm that the appointee is eligible to work in the UK before they start working for us. When applying for jobs it is important that you are aware of your eligibility status as government restrictions apply to the employment of migrant workers. If invited to interview, you will be required to provide proof of your eligibility to work in the UK on your arrival.

Due to the anticipated high number of applicants, we can only reply to candidates with the most relevant skills and experience. If you have not heard back from us within one month of submitting your application, please assume that you have been unsuccessful on this occasion.

Domainex is not accepting unsolicited assistance from search firms for any employment opportunities.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Domainex via email, the Internet or in any form and/or method without a valid written search agreement in place for any position will be deemed the sole property of Domainex.  No fee will be paid in the event the candidate is hired by Domainex as a result of the referral or through other means.