Cardiac muscle cell death plays a role in acute and chronic heart failure. On detecting cell death-inducing stimuli, cardiac muscle cells, or cardiomyocytes, activate MAP4K4, an ‘upstream’ member of the MAP kinase superfamily. Therefore, MAP4K4 knock-down could protect cardiomyocytes from these stimuli and prevent cell death.

Watch this video to hear Dr Gary Newton explain the rational, the approach to identify suitable inhibitors, and the translational opportunities of this multi-centre drug discovery collaboration

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