Mitochondrial membrane potential assays to determine compound effects on mitochondrial toxicity & pathology

Mitochondrial membrane potential is a key marker of bioenergetics and cellular health. At Domainex, we have created an assay to measure changes in mitochondrial membrane potential in response to environmental or genetic factors affecting mitochondrial oxidative phosphorylation. 

mitochondria

Measuring such changes is extremely valuable in: 

  • Determining if a compound has mitochondrial toxicity  

  • Understanding mitochondrial-associated pathology 

The cell assay uses the fluorescent dye tetramethylrhodamine methyl ester (TMRM) to measure mitochondrial membrane potential induced by chemical effectors. 

 

Mitochondrial diagram