High-Throughput Experimentation at Domainex

High-Throughput Experimentation (HTE) is a powerful technique for reaction optimisation; it enables multiple reaction variables to be assessed in parallel in one single experiment. HTE is beneficial because it minimises the amount of reagents used, which in addition to being time and cost effective, is a greener way of conducting chemistry. 

At Domainex, we have adopted HTE as part of our standard way of working and regularly use it to troubleshoot problematic reactions. Our HTE platform enables us to screen a range of reaction conditions more rapidly and use fewer starting materials compared to using the sequential, single experiment approach and facilitates the optimisation of reactions in less time. Identifying better reaction conditions not only improves the yields of reactions but also simplifies the purification and isolation of compounds, bringing significant time savings.